磷酸泰乐菌素

中文名称:

磷酸泰乐菌素

中文同义词:

泰乐菌素磷酸盐;磷酸泰乐菌素预混剂;泰乐霉素磷酸盐;磷酸泰乐菌素

英文名称:

Tylosin phosphate

英文同义词:

Pharmasine TB;Tylan 10 premix;Tylan 40 premix;Tyrosine [antibiotic]/phosphoric acid,(1:x);Einecs 215-779-4;ylosin phosphate;TYLAN;TYLOSIN PHOSPHATE

CAS号:

1405-53-4

分子式:

C46H80NO21P

分子量:

1014.1

EINECS号:

215-779-4

相关类别:

兽药原料;兽药原料药;医药兽药;抗菌;原料中间体-原料药;分析标准品;饲料添加剂;抗生素;Chemical Structure;Chromatography;DrugsMetabolites;Pharmacology StandardsAlphabetic;Principle;API;生命科学标准品;医药原料;Pyridines;feed additive;抗生素类;医用原料;原料;其他原料药;原料药;API原料药-兽药原料药;BacteriostaticForensic and Veterinary Standards;Neat CompoundsAntibiotics;OthersAnalytical Standards;Antibiotics;TP - TZ;Veterinaries

Mol文件:

1405-53-4.mol

储存条件 

2-8°C

形态

neat

CAS 数据库

1405-53-4(CAS DataBase Reference)

生物活性

Tylosin phosphate 是一种大环内酯类抗生素 (antibiotic)，是 Streptomyces fradiae 的产物。Tylosin phosphate 对革兰氏阳性菌具有高效的抗菌活性。Tylosin phosphate 是一种广泛用于促进动物生长的饲料添加剂。Tylosin phosphate 被用于治疗家禽、猪和牛的细菌性痢疾和呼吸道疾病。

靶点

Antibiotic

体外研究

Tylosin phosphate exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit . Tylosin phosphate also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for M. haemolytica 11935, P. multocida 4407, E. coli ATCC 25922 and E. coli AS19rlmA I , respectively.

体内研究

Tylosin phosphate (10-500 mg/kg; s.c.) generally suppresses the elevated TNF-α and IL-1β levels and increases the IL-10 levels in the Lipopolysaccharide (LPS) -treated animals. Animal Model: Balb/C mice (2-3 months old, 20-25 g) Dosage: 10 mg/kg, 100 mg/kg, 500 mg/kg Administration: Subcutaneous injection Result: Reduced the elevated TNF-α and IL-1β in LPS (250 µg)-treated mice but increased their IL-10 levels.

Animal Model:

Balb/C mice (2-3 months old, 20-25 g)

Dosage:

10 mg/kg, 100 mg/kg, 500 mg/kg

Administration:

Subcutaneous injection

Result:

Reduced the elevated TNF-α and IL-1β in LPS (250 µg)-treated mice but increased their IL-10 levels.

WGK Germany 

2

RTECS号

YP0625000

毒性

Tylosin base and its salts were shown to be of low acute oral toxicity with LD50 values in excess 5000 mg/kg bw in the rat and mouse and greater than 800 mg/kg bw in the dog.