苯唑青霉素钠

中文名称:

苯唑青霉素钠

中文同义词:

安迪灵;苯唑青;新青Ⅱ号;新青霉素;青霉素 P-12 钠盐;苯唑西林钠;苯甲异噁唑青霉素钠;新青霉素II

英文名称:

Oxacillin sodium monohydrate

英文同义词:

SODIUM OXACILLIN;OXACILLIN SODIUM;OXACILLIN NA;OXACILLIN SODIUM SALT HYDRATE VETRANAL,;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-diMethyl-6-[[(5-Methyl-3-phenyl-4-isoxazolyl)carbonyl]aMino]-7-oxo-,sodiuM salt, hydrate (1:1:1), (2S,5R,6R)-;Oxacillin sod;Oxacillin Sodium Salt ;(2S,5R,6R)-3,3-dimethyl-6-[[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, sodium salt, hydrate (1:1:1)

CAS号:

7240-38-2

分子式:

C19H18N3NaO5S

分子量:

423.42

EINECS号:

629-150-0

相关类别:

青霉素类;小分子抑制剂，天然产物;医药原料;其它试剂;抗生素及抗病毒;抗生素;医药化工类;医药原料药;Antibiotics for Research and Experimental Use;beta-Lactams (Antibiotics for Research and Experimental Use);Biochemistry;beta-Lactam StructureEPA;1694 PharmaceuticalsPersonal Care Products;Alphabetic;Antibiotics;BactericidalAntibiotics;Chemical Structure;NeatsAnalytical Standards;Stains and Dyes;StainsDyes, A to;原料药;医药、农药及染料中间体;生化试剂;化学试剂;O;Principle;Peptide Synthesis/Antibiotics;Inhibitors

Mol文件:

7240-38-2.mol

熔点 

188 C

比旋光度 

D20 +201° (c = 1 in water)

沸点 

687℃

折射率 

205 ° (C=1, H2O)

闪点 

>110°(230°F)

储存条件 

Refrigerator

溶解度 

Freely soluble in water, soluble in methanol, practically insoluble in methylene chloride.

形态

neat

PH值

pH (30g/l, 25℃) : 4.5～7.5

水溶解性 

Freely soluble in water

Merck 

14,6904

BRN 

4287093

CAS 数据库

7240-38-2(CAS DataBase Reference)

生物活性

Oxacillin sodium monohydrate (Methicillin)是一种抗菌剂，是一种窄谱，青霉素类的β-内酰胺类抗生素。

体外研究

Oxacillin exhibits MIC values of ≤1 μg/mL for four mecA gene-carrying S. aureus clinical isolates (SA 1306, SA 1326, SA 1552, and SA 4666. Oxacillin (5 μg/mL, 0-90 min) induces lysis of Tol + and Tol - strains. Cell Viability Assay Cell Line: Cells of S. aureus which had grown for six to eight generations in [ 14 C]glycerol. Concentration: 5 μg/mL. Incubation Time: 0, 30, 60, 90 min. Result: The Tol + isolates were readily distinguished from Tol- isolates by the rates at which the cells lysed.

Cell Line:

Cells of S. aureus which had grown for six to eight generations in [ 14 C]glycerol.

Concentration:

5 μg/mL.

Incubation Time:

0, 30, 60, 90 min.

Result:

The Tol + isolates were readily distinguished from Tol- isolates by the rates at which the cells lysed.

化学性质 

白色结晶性粉末。熔点188℃（分解），易溶于水、甲醇、二甲基亚砜，微溶于水乙醇、氯仿，极微溶于丙酮、丁醇，不溶于乙醚、苯。

用途 

半合成的耐酸耐酶青霉素。临床主要用于耐药金葡菌感染，如败血症、肺炎、化脓性脑膜炎和骨髓炎等。

生产方法 

6-氨基青霉烷酸与苯甲异噁唑酰氯缩合、成盐而得。

危险品标志 

Xn,Xi

危险类别码 

36/37/38-42/43

安全说明 

22-26-36/37

WGK Germany 

3

海关编码 

29411099

毒性

LD50 orally in rats: >8000 mg/kg (Goldenthal)