雌二醇

中文名称:

雌二醇

中文同义词:

17-ALPHA-雌二醇;alpha-雌二醇;1,3,5(10)雌甾三烯-3,17Α-二醇;17Α-雌二醇;3,17Α-二羟基-1,3,5(10)雌甾三烯;表雌二醇;雌甾-1,3,5(10)三烯-3,17Α-二醇;炔雌醇杂质L(EP)

英文名称:

Estradiol

英文同义词:

1,3,5-estratriene-3,17-alpha-diol;1,3,5-Estratriene-3,17alpha-diol;17alpha-Oestradiol;3,17alpha-Dihydroxyestra-1,3,5(10)-triene;3,17-alpha-dihydroxyoestra-1,3,5(10)-triene;3,17alpha-Dihydroxyoestra-1,3,5(10)-triene;5(10)-triene-3,17-diol,(17-alpha)-estra-3;epiestradial

CAS号:

57-91-0

分子式:

C18H24O2

分子量:

272.39

EINECS号:

200-354-8

相关类别:

抗生素、生物碱;甾体激素类;医药原料;医药原料药-科研原料;其它萜类;医药原材料;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals

Mol文件:

57-91-0.mol

 

 

熔点 

176-180 °C(lit.)

比旋光度 

D20 +53 to +56° (c = 0.9 in dioxane)

沸点 

355.44°C (rough estimate)

密度 

1.0708 (rough estimate)

折射率 

1.4800 (estimate)

储存条件 

0-6°C

溶解度 

ethanol: 50 mg/mL, clear, colorless

酸度系数(pKa)

10.27±0.60(Predicted)

形态

powder

颜色

white with slight yellow cast

水溶解性 

3.9mg/L(25 ºC)

Merck 

14,3704

CAS 数据库

57-91-0(CAS DataBase Reference)

NIST化学物质信息

Estra-1,3,5(10)-triene-3,17alpha-diol(57-91-0)

EPA化学物质信息

Estra-1,3,5(10)-triene-3,17-diol, (17.alpha.)- (57-91-0)

生物活性

Alpha-Estradiol 是一种雌性激素，是 5α-reductase 抑制剂，有潜力用于雄原性脱发的研究。

靶点

Human Endogenous Metabolite

靶点

Human Endogenous Metabolite

体外研究

Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.

体内研究

Alpha-Estradiol (17-alpha-estradiol, 0.01, 0.1, 1 μg) significantly reduces the percentage of central avascular/total retina area of the mouse pups. Alpha-Estradiol (1 μg) markedly decreasesmalondialdehyde (MDA) levels on postnatal days (PND) 9, 13, and 17 in retinas of hyperoxia-exposed pups. Alpha-Estradiol (1 μg) also decreases the number of NADPH-oxidase-positive cells, NADPH oxidase concentration and activity in retinas of the pups. In the 1.0-μg Alpha-Estradiol-treated pups, VEGF retinal concentrations are high on PND 9 but lower on PND 14 and 17. The best effect in retinas of 1.0-μg Alpha-Estradiol-treated pups is partly reversed by ICI182780 on PND 14 and 17.

用途 

治疗功能性子宫出血、原发性闭经、绝经期综合症等。

用途 

Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-螘stradiol and its selective receptor, ER-X, are not part of a cl assical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replac ement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer鈥檚 disease and ischemic stroke.

危险品标志 

T,Xn

危险类别码 

45-48-40

安全说明 

53-45-24/25-22

危险品运输编号 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS号

KG3750000

F 

8-10

海关编码 

29372390