可的松

中文名称:

可的松

中文同义词:

皮质酮/可的松;可的松-D2;甲醇中可的松溶液标准物质;11-去氢-17-羟皮质甾酮;17-羟-11-脱皮质酮;17-羟-11脱氢皮质酮;可的松;肾上腺皮质激素

英文名称:

CORTISONE

英文同义词:

17,21-Dihydroxy-4-pregnene-3,11,20-trione;17,21-Dihydroxypregn-4-ene-3,11,20-trione;20-trione,17,21-dihydroxy-pregn-4-ene-11;Adrenalex;Adreson;Andreson;Corlin;Cortadren

CAS号:

53-06-5

分子式:

C21H28O5

分子量:

360.44

EINECS号:

200-162-4

相关类别:

甾体激素 (激素，糖皮激素);甾体激素类;医药原料药;脂类;小分子抑制剂;小分子抑制剂，天然产物;激素;生化试剂;生物化学品;Steroids;Biochemistry;Hydroxyketosteroids;Intermediates Fine Chemicals;Pharmaceuticals;Intracellular receptor;Inhibitors;对照品;标准品 -中药标准品;医药原料

Mol文件:

53-06-5.mol

熔点 

223-228 °C (dec.)(lit.)

比旋光度 

D25 +209° (c = 1.2 in 95% alcohol); 25546 +269° (c = 0.125 in benzene); 25546 +248° (c = 0.1 to 0.2 in alcohol)

沸点 

412.46°C (rough estimate)

密度 

1.28±0.1 g/cm3 (20 ºC 760 Torr)

折射率 

210 ° (C=1, EtOH)

闪点 

9℃

储存条件 

-20°C Freezer

酸度系数(pKa)

12.37±0.60(Predicted)

水溶解性 

229.9mg/L(25 ºC)

Merck 

2539

CAS 数据库

53-06-5(CAS DataBase Reference)

生物活性

Cortisone是一种孕烷甾类激素，是身体应对压力应激时释放的主要物质。它能抑制免疫系统，从而减少炎症反应和炎性疼痛、伤处肿胀。

靶点

Human Endogenous Metabolite

Human Endogenous Metabolite

体外研究

Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).

体内研究

Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits. Animal Model: Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion Dosage: 2 mg/kg Administration: Intramuscular injection on alternate days for 2 months Result: Reduced the BCG lesions and tuberculin reactions. Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.

Animal Model:

Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion

Dosage:

2 mg/kg

Administration:

Intramuscular injection on alternate days for 2 months

Result:

Reduced the BCG lesions and tuberculin reactions. Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.

化学性质 

白色结晶性粉末。Mp220-224℃(部分分解)，比旋光度[α]25D+209°(1.2%，95%乙醇)、[α]25546+269°(0.125%，苯)。溶于甲醇、乙醇、丙酮；微溶于乙醚、氯仿和苯；难溶于水，水溶液呈中性。在浓硫酸中呈橙红色，并显绿色荧光。

用途 

生化研究；皮质激素类药物，具有抗炎、抗过敏等作用。

用途 

为肾上腺皮质激素类药，适用于治疗活动性风湿症、类风湿关节炎、过敏性皮炎及过敏恶性循性结膜炎等病

生产方法 

以醋酸孕甾双烯醇酮为原料，依次经过氧化氢氧化、沃氏氧化、黑根菌生物氧化、铬酐氧化得11-酮基-16，17α环氧黄体酮，经氢溴酸开环，氢化脱溴得粗品，再重结晶制得。

危险品标志 

F,T,Xn

危险类别码 

11-23/24/25-39/23/24/25-63

安全说明 

22-24/25-45-36/37-16-7

危险品运输编号 

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 

3

RTECS号

GM9020000

F 

18

海关编码 

2937210000