3-氯-L-丙氨酸

中文名称:

3-氯-L-丙氨酸

中文同义词:

3-氯-L-丙氨酸 (R)-2-AMINO-3-CHLOROPROPANOIC ACID;(R)-2-氨基-3-氯丙酸;(S)-3-氯丙氨酸;3-氯-L-丙氨酸;L-3-氯丙氨酸;3-氯-L-丙氨酸-15N;Β-CHLORO-L-ALANINE

英文名称:

3-Chloro-L-alanine

英文同义词:

H-BETA-CHLORO-ALA-OH;H-ALA(BETA-CL)-OH;H-ALA(3-CL)-OH;L-ALA-3-CL;BETA-CHLORO-ALANINE;BETA-CHLORO-L-ALANINE;S-3-Cl-Alanine;B-Chloro-L-Alanine

CAS号:

2731-73-9

分子式:

C3H6ClNO2

分子量:

123.54

EINECS号:

相关类别:

医药中间体、非天然氨基酸;氨基酸及其衍生物-特殊氨基酸;氨基酸

Mol文件:

2731-73-9.mol

熔点 

156 °C

沸点 

243.6±30.0 °C(Predicted)

密度 

1.2776 (rough estimate)

折射率 

1.5000 (estimate)

储存条件 

Keep in dark place,Inert atmosphere,2-8°C

酸度系数(pKa)

1.89±0.10(Predicted)

水溶解性 

soluble

CAS 数据库

2731-73-9

生物活性

β-Chloro-L-alanine是抑制多种酶的抑菌氨基酸类似物，抑制包括苏氨酸脱氨酶和丙氨酸消旋酶。

靶点

Bacterial

体外研究

β-Chloro-L-alanine can inhibit threonine deaminase, the branched-chain amino acid transaminase (transaminase B), L-aspartate-pdecarboxylase, alanine racemase and probably O-acetylserine sulfhydrylase. β-Chloro-L-alanine reversibly inhibits the Escherichia coli K-12 alanine-valine transaminase, transaminase C. This inhibition, along with the inhibition of transaminase B, account for the isoleucine-plus-valine requirement of Escherichia coli in the presence of β-Chloro-L-alanine. Salmonella typhimurium LT2 will grow in the presence of BCA if isoleucine and valine are added to the medium and presume that the growth requirement is due to the inhibition of transaminase B.

安全说明 

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