3,3-二碘甲腺原氨酸

中文名称:

3,3-二碘甲腺原氨酸

中文同义词:

左旋甲状腺素杂质13;二碘甲腺原氨酸;3,3-二碘甲腺氨酸;3,3ˊ-二碘-L-甲状腺原氨酸;L-3,3-二碘甲腺原氨酸;3,3-二碘甲腺原氨酸;O-(对羟基苯基)-3,3-二碘-L-酪氨酸;3,3-二碘甲状腺原氨酸

英文名称:

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine

英文同义词:

O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine;3,5-Diiodo-L-tyrosinedihydrae;(S)-α-Amino-4-[(4-hydroxy-3-iodophenyl)oxy]-3-iodobenzenepropanoic acid;3-Iodo-O-(4-hydroxy-3-iodophenyl)-L-tyrosine;O-(3-Iodo-4-hydroxyphenyl)-3-iodo-L-tyrosine;3,3-Diiodo-L-thyronine;(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3-iodophenyl]propanoic acid;(2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3-iodo-phenyl]propionic acid

CAS号:

4604-41-5

分子式:

C15H13I2NO4

分子量:

525.08

EINECS号:

225-005-7

相关类别:

杂环化合物;Amino Acids Derivatives;Labeling and Diagnostics Reagents

Mol文件:

4604-41-5.mol

熔点 

178-180°C

沸点 

520.7±50.0 °C(Predicted)

密度 

2.095±0.06 g/cm3(Predicted)

储存条件 

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

酸度系数(pKa)

2.17±0.20(Predicted)

生物活性

3,3-Diiodo-L-thyronine (3,3-T2) 是一种甲状腺激素的内源性代谢产物 (endogenous metabolite)。3,3-Diiodo-L-thyronine 显着增强 COX 活性。

靶点

Human Endogenous Metabolite COX

Human Endogenous Metabolite

COX

体外研究

3,3-Diiodo-L-thyronine (3,3-T2; 1 μM; 30 min) significantly enhances COX activity. 3,3-Diiodo-L-thyronine of 1 μM has the maximum effect. 3,3-Diiodo-L-thyronine is produced by further degradation of T3 and rT3.

WGK Germany 

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