1,2-二油酰-SN-甘油-3-磷酰乙醇胺

中文名称:

1,2-二油酰-SN-甘油-3-磷酰乙醇胺

中文同义词:

阳离子脂质体DOPE;SIRNA脂质体DOPE;1,2-二油酰基-SN-丙三基-3-磷脂酰乙醇胺;二油酰磷脂酰乙醇胺DOPE;1,2-二油酰基-SN-丙三基-3-磷脂酰乙醇胺;二油酰基 L-Α-磷脂酰乙醇胺;1,2-二油酰-SN-甘油-3-磷酸乙醇胺;二油酰基磷脂酰乙醇胺

英文名称:

1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE

英文同义词:

3-SN-PHOSPHATIDYLETHANOLAMINE, 1,2-DIDEOYL;1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE;1,2-DI([CIS]-9-OCTADECENOYL)-SN-GLYCERO-3-PHOSPHOETHANOLAMINE;18:1 PE;L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL;L-ALPHA-PHOSPHATIDYLETHANOLAMINE, DIOLEOYL (C18:1,[CIS]-9);L-BETA,GAMMA-DIOLEOYL-ALPHA-CEPHALIN;DIOLEOYL PHOSPHATIDYL ETHANOLAMINE

CAS号:

4004-05-1

分子式:

C41H78NO8P

分子量:

744.05

EINECS号:

200-663-8

相关类别:

酯;合成磷脂

Mol文件:

4004-05-1.mol

熔点 

200°C(lit.)

沸点 

759.2±70.0 °C(Predicted)

密度 

1.008±0.06 g/cm3(Predicted)

储存条件 

-20°C

酸度系数(pKa)

1.17±0.50(Predicted)

形态

lyophilized powder

BRN 

1718431

生物活性

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) 是阳离子脂质体的中性辅助脂质 (helper lipid)，与阳离子磷脂结合，提高裸 siRNA 的转染效率。

靶点

IC50: helper lipid for liposome

体外研究

In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent).With the neutral lipid for the LNP is DOPE , LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity.LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells.LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs.

危险品标志 

Xn

危险类别码 

22-38-40-48/20/22-67-36/38-20-63

安全说明 

36/37-26

危险品运输编号 

UN 1888 6.1/PG 3

WGK Germany 

3

F 

8-10-23

海关编码 

29232000