中文名称:

TLR4-IN-C34

中文同义词:

ISOPROPYL 2-(ACETYLAMINO)-2-DEOXY á-D-GLUCOPYRANOSIDE 3,4,6-TRIACETATE

英文名称:

Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate

英文同义词:

2-Acetamidopyranoside;C34;Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate;TLR4-IN-C34;TLR4-C34;Isopropyl 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-alpha-D-glucopyranoside, Min. 98%;1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate;1-Methylethyl 2-(acetylamino)-2-deoxy-a-Dglucopyranoside 3,4,6-triacetate

CAS号:

40592-88-9

分子式:

C17H27NO9

分子量:

389.39758

EINECS号:

相关类别:

抑制剂;API

Mol文件:

40592-88-9.mol

储存条件 

-20°C

溶解度 

H2O: soluble1mg/mL, clear (warmed)

形态

powder

颜色

white to beige

用途

TLR4-IN-C34是一类新的toll样受体4 (TLR4)抑制剂，是潜在的抗炎药物。

生物活性

TLR4-IN-C34 是具有口服活性的 TLR4 抑制剂，可改善内毒素血症和坏死性小肠结肠炎模型的全身炎症。

体内研究

TLR4-IN-C34 (C34, 1 mg/kg, orally daily) could attenuate NEC severity and demonstrates a marked preservation of the intestinal mucosa. Animal Model: Experimental NEC induced in 7-8 day old mice. Dosage: 1 mg/kg. Administration: Orally every morning. Result: Attenuated intestinal inflammation.

Animal Model:

Experimental NEC induced in 7-8 day old mice.

Dosage:

1 mg/kg.

Administration:

Orally every morning.

Result:

Attenuated intestinal inflammation.

WGK Germany 

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