二氰蒽醌
中文名称:
二氰蒽醌
中文同义词:
75%二氰蒽醌可湿性粉剂;二氰蒽醌悬浮剂;二氰蒽醌 (二噻农);二氰蒽醌溶液, 1000PPM;二嗪农/二氰蒽醌;二噻农(标准品);二氰蒽醌溶液,100PPM;3-二氰基-1
英文名称:
DITHIANON
英文同义词:
1,4-dithiaanthraquinone-2,3-dicarbonitrile;3-b)-p-dithiin-2,3-dicarbonitrile,5,10-dihydro-5,10-dioxo-naphtho(;3-b]-1,4-dithiin-2,3-dicarbonitrile,5,10-dihydro-5,10-dioxo-Naphtho[2;5,10-dihydroxy-5,10-dioxonaphtho-(2,3,b)-p-dithiin-2,3-dicarbonitrile;delan(fungicide);dithianone;it931;dithianon (bsi,iso,jmaf)
CAS号:
3347-22-6
分子式:
C14H4N2O2S2
分子量:
296.32
EINECS号:
222-098-6
相关类别:
有机原料;农药中间体;中间体;农残、兽药及化肥类;杀菌剂类;NULL;Alpha sort;D;DAlphabetic;DIO - DIZPesticides;Fungicides;PesticidesMetabolites;Quinones
Mol文件:
3347-22-6.mol
熔点
225°
沸点
402.1±45.0 °C(Predicted)
密度
d18 1.55
折射率
1.6360 (estimate)
储存条件
0-6°C
形态
neat
水溶解性
0.5mg/L(temperature not stated)
Merck
13,3404
BRN
1325563
CAS 数据库
3347-22-6(CAS DataBase Reference)
NIST化学物质信息
Dithianone(3347-22-6)
EPA化学物质信息
Dithianon (3347-22-6)
应用
二氰蒽醌是一种醌类结构的具有多作用位点杀菌剂，通过与含硫基团反应和干扰细胞呼吸而抑制一系列真菌酶，最后导致病害死亡。具有很好的保护活性的同时，也有一定的治疗活性。
生物活性
Dithianon 是一种广谱蒽醌类杀菌剂，对叶子和果实的表面具有良好的附着力。Dithianon 用于控制某些水果和蔬菜上的几种真菌，如炭疽病菌 (Colletotrichum sp., Elsinoe ampelina)，霉菌 (Plasmopara viticola)，磷光菌 (Phomopsis viticola) 等。
靶点
Reactive oxygen species (ROS)
Colletotrichum sp. ; Elsinoe ampelina ; Plasmopara viticola ; Phomopsis viticola
体外研究
When exponentially aerobic growing cells of S. cerevisiae are submitted to acute Dithianon treatment they loss cell wall and membrane integrity, dying by necrosis, and this behavior is associated to a depletion of reduced proteic and non-proteic thiol groups. An important increase of cellular reactive oxygen species (ROS) associated to mitochondrial membrane potential modifications on Dithianon treated cells are also detected.
In filamentous fungus, Dithianon inhibits mycelial growth and conidial germination. Studies on Ehrlich ascites carcinoma and yeast cells showed that Dithianon inhibits respiration and fermentation affecting several thiol enzymes of the glycolytic pathway as hexokinase, phosphofructokinase, and glyceraldeyde-3-phosphate dehydrogenase.
Dithianon has in vitro cytotoxic effect and affect cell transforming activity of BLAB/c 3 T3 cells.
体内研究
The activity of testosterone hydroxylase of liver microsomes derived from male mice is increased when they are treated with acute doses of Dithianon, while in females an inactivating effect is observed.
危险品标志
Xn;N,N,Xn
危险类别码
22-50/53
安全说明
24-60-61
危险品运输编号
UN 3077
WGK Germany
3
RTECS号
QL0700000
HazardClass
6.1(b)
PackingGroup
III
海关编码
29349990
毒害物质数据
3347-22-6(Hazardous Substances Data)
毒性
LD50 orally in rats, guinea pigs: 638, 110 mg/kg (Amadori, Heupt)
