炔诺酮醋酸酯

中文名称:

炔诺酮醋酸酯

中文同义词:

炔诺酮乙酸酯;醋酸炔诺酮溶液,100PPM;17Α-乙炔基-17Β-羟基雌甾-4-烯-3-酮17-醋酸酯;17Α-乙炔基雌甾-4-烯-17Β-醇-3-酮17-醋酸酯;17Β-乙酰氧基-17Α-乙炔基雌甾-4-烯-3-酮;17β-羟基9-去甲-17α-孕甾-4-烯-20-炔-3-酮-17-醋酸酯;炔诺酮醋酸脂;炔诺酮醋酸盐

英文名称:

19-Norethindrone acetate

英文同义词:

SH-420C;4-ESTREN-17ALPHA-ETHYNYL-17BETA-OL-3-ONE 17-ACETATE;4-ESTREN-17-ALPHA-ETHYNYL-17-BETA-OL-3-ONE ACETATE;ACETIC ACID 17-ETHYNYL-13-METHYL-3-OXO-2,3,6,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPE;19-NORETHISTERONE 17-ACETATE MIN. 98 % (;NORETHISTERONE ACETATE, EP STANDARD;NORETHISTERONE ACETATE, IMP. A (EP): NORETHISTERONE MM(CRM STANDARD);NORETHISTERONE ACETATE, WHO STANDARD

CAS号:

51-98-9

分子式:

C22H28O3

分子量:

340.46

EINECS号:

200-132-0

相关类别:

医药中间体;原料药;甾体激素类;甾体激素 (激素，糖皮激素);医药原料;对照品;化学试剂;Active Pharmaceutical Ingredients;Acetylenes;Biochemistry;Functionalized Acetylenes;Hydroxyketosteroids;Steroids;Intermediates Fine Chemicals;Pharmaceuticals;Steroid and Hormone;AYGESTIN

Mol文件:

51-98-9.mol

熔点

161-162°

沸点

416.25°C (rough estimate)

密度

1.1236 (rough estimate)

折射率

-34 ° (C=1, Dioxane)

储存条件

2-8°C

溶解度

Practically insoluble in water, freely soluble in methylene chloride, soluble in alcohol.

形态

neat

颜色

Crystals from Me2CO/hexane

水溶解性

3.162mg/L(10 ºC)

Merck

14,6697

InChIKey

IMONTRJLAWHYGT-ZCPXKWAGSA-N

CAS 数据库

51-98-9(CAS DataBase Reference)

NIST化学物质信息

Norethindrone acetate(51-98-9)

生物活性

Norethindrone acetate 是一种雌性激素，可用于子宫内膜异位症研究。

靶点

Progesterone Receptor

体内研究

Norethindrone acetate could be a cost-effective alternative with relatively mild side effects in the treatment of symptomatic endometriosis. Subjects treated with norethindrone acetate obtain dysmenorrhea and noncyclic pelvic pain relief. Norethindrone acetate alone is a well-tolerated, effective option to manage pain and bleeding for all stages of endometriosis. Post-Norethindrone acetate bleeding scores are improved regardless of prior hormonal regimen, and post-Norethindrone acetate pain scores improved in all patients except for those previously prescribed GnRH-agonist plus add-back. Norethindrone acetate shows low acute toxicity in experimental animals and is consistent with the lack of toxicity seen in humans. Administration of norethindrone acetate alone to rodents at several multiples of the human dose results in no treatment related mortality, hematological changes, behavioral changes, or organ pathology. Norethindrone acetate administration leads to significant and proportional reductions of the concentrations of triglycerides, cholesterol and phospholipids of plasma lipoproteins of density <1.006 of rats fed a high carbohydrate diet. Norethindrone acetate (0.1 mM) also significantly inhibits the incorporation of both palmitate and glycerol into triglycerides of isolated hepatocytes from fed rats.

用途

孕激素类药，用于月经不调、子宫功能性出血、子宫内膜异位症等。

危险品标志

危险类别码

40-48

安全说明

36/37

WGK Germany

RTECS号

RC8965000

海关编码

29372390