中文名称:

POLYMYXIN B NONAPEPTIDE

中文同义词:

多粘菌素B九肽;阿维巴坦杂质66;多粘菌素B盐酸盐

英文名称:

POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE

英文同义词:

POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE;polymyxinbnonapeptide;N2-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-);N2-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-Thr-);Nα-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-);PMBN;sPMBN;2-10-Polymyxin B1

CAS号:

86408-36-8

分子式:

C43H74N14O11

分子量:

963.13

EINECS号:

相关类别:

多肽;多肽;Other Peptides;Peptides and Proteins;Peptides for Cell Biology

Mol文件:

86408-36-8.mol

储存条件 

2-8°C

生物活性

Polymyxin B nonapeptide 是一种阳离子环肽。Polymyxin B nonapeptide 是经酶裂解 Polymyxin B 而产生的衍生物，与 Polymyxin B 相比，Polymyxin B nonapeptide 毒性低，缺乏杀菌活性，仍具有破坏革兰氏阴性菌外膜的能力。

体外研究

Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS).

WGK Germany 

3