中文名称:

3-[3-[(2E)-3,7-二甲基-2,6-辛二烯-1-基]-4-羟基苯基]-7-羟基-4H-1-苯并吡喃-4-酮

中文同义词:

CORYLIFOL A(标准品);3-[3-[(2E)-3,7-二甲基-2,6-辛二烯-1-基]-4-羟基苯基]-7-羟基-4H-1-苯并吡喃-4-酮;6-辛二烯-1-基]-4-羟基苯基]-7-羟基-4H-1-苯并吡喃-4-酮;补骨脂异黄酮A;次甘酸查耳酮;次苷酸查尔酮;化合物CORYLIFOL A

英文名称:

3-[3-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one

英文同义词:

3-[3-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one;3-Geranyl-4,7-dihydroxyisoflavone;CORYLIFOL A;3-GERANYL-4,7-DIHYDROXYISOFLAVONE; CORYLININ;Corylifol A;Corylinin;3-[3-[(2E)-3;6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one;7-Dimethyl-2

CAS号:

775351-88-7

分子式:

C25H26O4

分子量:

390.47

EINECS号:

相关类别:

标准品;植物提取物;对照品;标准品 -对照药材;黄酮;标准品，对照品

Mol文件:

775351-88-7.mol

沸点 

609.3±55.0 °C(Predicted)

密度 

1.191

酸度系数(pKa)

6.92±0.20(Predicted)

生物活性

Corylifol A 能够抑制IL-6 诱导的 STAT3 的激活和磷酸化，其IC50 值为0.81 μM。

靶点

STAT3 0.81 μM (IC 50 )

STAT3 0.81 μM (IC 50 )

体外研究

Corylifol A shows an inhibitory effect on IL-6-induced STAT3 promoter activity in Hep3B cells with IC 50 value of 0.81±0.15 μM, also inhibits STAT3 phosphorylation induced by IL-6 in Hep3B cells. Corylifol A inhibits SARA PLpro in a dose-dependent manner with IC 50 s ranging between 4.2 and 38.4 μM. Corylifol A is found to be a naturally occurring potent inhibitor of hCE2, with low K i values ranging from 0.62 μM to 3.89 μM.