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L-硒代蛋氨酸

中文名称:
L-硒代蛋氨酸
中文同义词:
L(+)硒代蛋氨酸;L-硒代蛋氨;硒代蛋氨酸;L-(+)-硒代蛋氨酸;硒基-L-甲硫氨酸;(S)-(+)-2-氨基-4-(甲基硒)丁酸;-硒代蛋氨酸;L-SELENOMETHIONINE L-硒代蛋氨酸
英文名称:
L-Selenomethionine
英文同义词:
(S)-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID;(S)-2-AMINO-4-(METHYLSELENO)BUTYRIC ACID;SEMET;SELENOMETHIONINE, L-(+)-;SELENO-L-METHIONINE;L-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID;L-(+)-SELENOMETHIONINE;L-SELENOMETHIONINE
CAS号:
3211-76-5
分子式:
C5H11NO2Se
分子量:
196.11
EINECS号:
608-705-0
相关类别:
医药原料药;化学试剂;氨基酸类;细胞信号和神经生物学;食品添加剂;氨基酸;新材料;对照品;功能性物质-硒代蛋氨酸;生化试剂-氨基酸类;化工;L-硒代蛋氨酸;化工原料;原料;医药原料;医用原料;食品添加;优势产品;Amino Acid Derivatives;Methionine [Met, M];Amino Acids;Antioxidant;Biochemistry;Biological-modified Amino Acids;Classes of Metal Compounds;Se (Selenium) Compounds;Semimetal Compounds;Seleno Amino Acid;amino acid;饲料添加剂;其他
Mol文件:
3211-76-5.mol
熔点 
265 °C
比旋光度 
18 º (c=1, 1N HCl)
沸点 
320.8±37.0 °C(Predicted)
折射率 
18 ° (C=0.5, 2mol/L HCl)
储存条件 
−20°C
溶解度 
H2O: 50 mg/mL
形态
powder
酸度系数(pKa)
2.26±0.10(Predicted)
颜色
white to off-white
水溶解性 
soluble
Merck 
14,8441
InChIKey
RJFAYQIBOAGBLC-BYPYZUCNSA-N
CAS 数据库
3211-76-5(CAS DataBase Reference)
生物活性
L-SelenoMethionine 是 Selenomethionine 的 L-异构体，是硒的主要天然食物形式。L-SelenoMethionine 是一种癌症化学预防剂，可以通过饮食补充降低癌症的发生率并诱导癌细胞凋亡。L-SelenoMethionine 还可以增加谷胱甘肽过氧化物酶的表达。
靶点
Human Endogenous Metabolite
Human Endogenous Metabolite
体外研究
L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells. L-SelenoMethionine (500 μM; 48 h) induce apoptosis in prostate cancer cells. L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells. L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation. Cell Viability Assay Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) Concentration: 1, 5, 10, 50, 100, 500 μM Incubation Time: 24, 48, 72 hours Result: Inhibited the growth of prostate cancer cells, with a lower IC 50 (1-90 μM) at 72 h than normal prostate cells (>500 μM). Apoptosis Analysis Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) Concentration: 500 μM Incubation Time: 48 hours Result: Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells. Exhibited the nicked-end DNA labeling in prostate cancer cells. Promoted the PARP cleavage in prostate cancer cells. Cell Cycle Analysis Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) Concentration: 500 μM Incubation Time: 48 hours Result: Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%). Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells. RT-PCR Cell Line: Human thyroid epithelial cells (HTori-3) Concentration: 5 μM Incubation Time: 24 hours Result: Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells.
Cell Line:
Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration:
1, 5, 10, 50, 100, 500 μM
Incubation Time:
24, 48, 72 hours
Result:
Inhibited the growth of prostate cancer cells, with a lower IC 50 (1-90 μM) at 72 h than normal prostate cells (>500 μM).
Cell Line:
Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration:
500 μM
Incubation Time:
48 hours
Result:
Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells. Exhibited the nicked-end DNA labeling in prostate cancer cells. Promoted the PARP cleavage in prostate cancer cells.
Cell Line:
Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration:
500 μM
Incubation Time:
48 hours
Result:
Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%). Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells.
Cell Line:
Human thyroid epithelial cells (HTori-3)
Concentration:
5 μM
Incubation Time:
24 hours
Result:
Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells.
体内研究
L-SelenoMethionine (0.06-12 μg/g diet; p.o. for 3 d) partially or completely prevent the decrease in the serum or plasma levels of total antioxidants in rats exposed to gamma rays, protons or HZE particles.
用途 
可以用于蛋白质的结构分析。拿此产品来饲养细菌，这样最终形成的蛋白质里的特定位置就会被硒所取代，便于结构测定
危险品标志 
T,N
危险类别码 
23/25-33-50/53
安全说明 
20/21-28-45-60-61-28A
危险品运输编号 
UN 3283 6.1/PG 2
WGK Germany 
3
RTECS号
EK7713840
F 
10
HazardClass 
6.1
PackingGroup 
III
海关编码 
29309090
价       格：请咨询卖家
CAS    号： 3211-76-5
规       格：10g/20g/100g/1kg
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详细介绍
英文名:
L-Selenomethionine
外观：
纯度：
请咨询卖家
分子式：
C5H11NO2Se
分子量：
196.11
中文名称:
L-硒代蛋氨酸
中文同义词:
L(+)硒代蛋氨酸;L-硒代蛋氨;硒代蛋氨酸;L-(+)-硒代蛋氨酸;硒基-L-甲硫氨酸;(S)-(+)-2-氨基-4-(甲基硒)丁酸;-硒代蛋氨酸;L-SELENOMETHIONINE L-硒代蛋氨酸
英文名称:
L-Selenomethionine
英文同义词:
(S)-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID;(S)-2-AMINO-4-(METHYLSELENO)BUTYRIC ACID;SEMET;SELENOMETHIONINE, L-(+)-;SELENO-L-METHIONINE;L-(+)-2-AMINO-4-(METHYLSELENO)BUTANOIC ACID;L-(+)-SELENOMETHIONINE;L-SELENOMETHIONINE
CAS号:
3211-76-5
分子式:
C5H11NO2Se
分子量:
196.11
EINECS号:
608-705-0
相关类别:
医药原料药;化学试剂;氨基酸类;细胞信号和神经生物学;食品添加剂;氨基酸;新材料;对照品;功能性物质-硒代蛋氨酸;生化试剂-氨基酸类;化工;L-硒代蛋氨酸;化工原料;原料;医药原料;医用原料;食品添加;优势产品;Amino Acid Derivatives;Methionine [Met, M];Amino Acids;Antioxidant;Biochemistry;Biological-modified Amino Acids;Classes of Metal Compounds;Se (Selenium) Compounds;Semimetal Compounds;Seleno Amino Acid;amino acid;饲料添加剂;其他
Mol文件:
3211-76-5.mol
熔点 
265 °C
比旋光度 
18 º (c=1, 1N HCl)
沸点 
320.8±37.0 °C(Predicted)
折射率 
18 ° (C=0.5, 2mol/L HCl)
储存条件 
−20°C
溶解度 
H2O: 50 mg/mL
形态
powder
酸度系数(pKa)
2.26±0.10(Predicted)
颜色
white to off-white
水溶解性 
soluble
Merck 
14,8441
InChIKey
RJFAYQIBOAGBLC-BYPYZUCNSA-N
CAS 数据库
3211-76-5(CAS DataBase Reference)
生物活性
L-SelenoMethionine 是 Selenomethionine 的 L-异构体，是硒的主要天然食物形式。L-SelenoMethionine 是一种癌症化学预防剂，可以通过饮食补充降低癌症的发生率并诱导癌细胞凋亡。L-SelenoMethionine 还可以增加谷胱甘肽过氧化物酶的表达。
靶点
Human Endogenous Metabolite
Human Endogenous Metabolite
体外研究
L-SelenoMethionine (1-500 μM; 24-72 h) is selectively inhibits the growth of prostate cancer cells, compared with normal cells. L-SelenoMethionine (500 μM; 48 h) induce apoptosis in prostate cancer cells. L-SelenoMethionine (500 μM; 48 h) causes an increase in arrest in the G2-M phase of the cell cycle selectively in prostate cancer cells. L-SelenoMethionine (5 μM; 24 h) mitigates gene expression associated with the cellular stress response from 10 cGy irradiation. Cell Viability Assay Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) Concentration: 1, 5, 10, 50, 100, 500 μM Incubation Time: 24, 48, 72 hours Result: Inhibited the growth of prostate cancer cells, with a lower IC 50 (1-90 μM) at 72 h than normal prostate cells (>500 μM). Apoptosis Analysis Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) Concentration: 500 μM Incubation Time: 48 hours Result: Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells. Exhibited the nicked-end DNA labeling in prostate cancer cells. Promoted the PARP cleavage in prostate cancer cells. Cell Cycle Analysis Cell Line: Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt) Concentration: 500 μM Incubation Time: 48 hours Result: Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%). Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells. RT-PCR Cell Line: Human thyroid epithelial cells (HTori-3) Concentration: 5 μM Incubation Time: 24 hours Result: Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells.
Cell Line:
Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration:
1, 5, 10, 50, 100, 500 μM
Incubation Time:
24, 48, 72 hours
Result:
Inhibited the growth of prostate cancer cells, with a lower IC 50 (1-90 μM) at 72 h than normal prostate cells (>500 μM).
Cell Line:
Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration:
500 μM
Incubation Time:
48 hours
Result:
Exhibited the highest level of DNA condensation in androgen-responsive LNCaP carcinoma cells, followed by PC-3 and DU145 cells. Exhibited the nicked-end DNA labeling in prostate cancer cells. Promoted the PARP cleavage in prostate cancer cells.
Cell Line:
Prostate cancer cells (LNCaP, PC-3, and DU145) and normal prostate cells (PrEC, PrSM, and PrSt)
Concentration:
500 μM
Incubation Time:
48 hours
Result:
Increased the sub-G0-G1 cell fraction of LNCaP (41.5%), PC-3 (12.1%), and DU145 cells (11.2%). Caused a significant increases in G2 cells , particularly in LNCaP (13%), PC-3 (32%), and DU145 (20%) cells.
Cell Line:
Human thyroid epithelial cells (HTori-3)
Concentration:
5 μM
Incubation Time:
24 hours
Result:
Downregulated the CDC6, GADD45A, FAS and ATF3 in irradiated cells.
体内研究
L-SelenoMethionine (0.06-12 μg/g diet; p.o. for 3 d) partially or completely prevent the decrease in the serum or plasma levels of total antioxidants in rats exposed to gamma rays, protons or HZE particles.
用途 
可以用于蛋白质的结构分析。拿此产品来饲养细菌，这样最终形成的蛋白质里的特定位置就会被硒所取代，便于结构测定
危险品标志 
T,N
危险类别码 
23/25-33-50/53
安全说明 
20/21-28-45-60-61-28A
危险品运输编号 
UN 3283 6.1/PG 2
WGK Germany 
3
RTECS号
EK7713840
F 
10
HazardClass 
6.1
PackingGroup 
III
海关编码 
29309090
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