中文名称:

21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮

中文同义词:

21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮;克拉司酮;克拉斯酮;CLASCOTERONE原料药;克拉考特酮

英文名称:

17alpha-propionate

英文同义词:

17alpha-propionate;CB-03-1;17alpha-propio17-(1-oxopropoxy)pregn-4-ene-3,20-dione;CB-03-01 17alpha-propionate;CB-03-01;Cortexolone 17-alpha-propionate;17 alpha-propionate (CB-03-01);21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione

CAS号:

19608-29-8

分子式:

C24H34O5

分子量:

402.52

EINECS号:

685-282-9

相关类别:

信号转导通路激酶抑制剂;医药抗结剂;科研原料;原料药;生发洗护系列;中间体;抑制剂;原料药;标准品;化工原料;APIS;化学试剂

Mol文件:

19608-29-8.mol

沸点 

538.9±50.0 °C(Predicted)

密度 

1.19

酸度系数(pKa)

12.98±0.10(Predicted)

用途

21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮用作有机合成、医药中间体。

生物活性

Clascoterone (Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, CB-03-01) 是一种局部的和外周选择性的 androgen receptor (AR) 的拮抗剂。

靶点

Target Value AR ()

Target

Value

AR ()

体内研究

Clascoterone is a new potent topical antiandrogen potentially useful in acne vulgaris. Clascoterone 1% cream was very well tolerated, and was significantly better than placebo regarding TLC (P = 0·0017), ILC (P = 0·0134) and ASI (P = 0·0090), and also clinically more effective than comparator. The product also induced a faster attainment of 50% improvement in all the above parameters.

用途 

信号转导通路激酶抑制剂