地诺前列素
中文名称:
地诺前列素
中文同义词:
前列腺素F2A/地诺前列素S;前列腺素 F2Α;前列腺素 F2a;地诺前列素;前列腺素F2Α
英文名称:
Prostaglandin F2a
英文同义词:
PROSTAGLANDIN F2ALPHA;PGF2ALPHA;9ALPHA,11ALPHA,15S-TRIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID;cyclosin;dinolytic;enzaprost;enzaprostf;glandin
CAS号:
551-11-1
分子式:
C20H34O5
分子量:
354.48
EINECS号:
215-355-9
相关类别:
前列腺素类;前列素类;合成;引产药;中间体;科研试剂;Chiral Reagents;Prostaglandins;Intermediates Fine Chemicals;Pharmaceuticals
Mol文件:
551-11-1.mol
熔点
25-35°
比旋光度
D25 +23.5° (c = 1 in tetrahydrofuran)
沸点
407.69°C (rough estimate)
密度
1.0458 (rough estimate)
折射率
1.6120 (estimate)
酸度系数(pKa)
pKa 4.90(H2O,t=25±2,I=0.0，c<0.01,N2) (Uncertain)
形态
Low melting white solid or colorless oil.
CAS 数据库
551-11-1(CAS DataBase Reference)
生物活性
Dinoprost (Prostaglandin F2α) 是一种口服有效的前列腺素 F (PGF) 受体 (FP receptor) 激动剂。Dinoprost 是在子宫内膜腔上皮和黄体 (CL) 中局部产生的溶酶激素。Dinoprost 在分娩过程中起关键作用。
靶点
Human Endogenous Metabolite
FP Receptor
Human Endogenous Metabolite
FP Receptor
体外研究
Dinoprost (Prostaglandin F2α; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells.
Dinoprost (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors.
Apoptosis Analysis
Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: Significantly increased the apoptotic rate (15.62±3.12%).
Cell Autophagy Assay
Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.
Western Blot Analysis
Cell Line: Goat luteal cells
Concentration: 1 μM
Incubation Time: For 24 hours
Result: The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.
Cell Line:
Goat luteal cells
Concentration:
1 μM
Incubation Time:
For 24 hours
Result:
Significantly increased the apoptotic rate (15.62±3.12%).
Cell Line:
Goat luteal cells
Concentration:
1 μM
Incubation Time:
For 24 hours
Result:
There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.
Cell Line:
Goat luteal cells
Concentration:
1 μM
Incubation Time:
For 24 hours
Result:
The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.
毒害物质数据
551-11-1(Hazardous Substances Data)
毒性
LD50 in rabbits (mg/kg): 2.5-5.0 i.v.; 2.5-5.0 i.m. (Fujita)
