中文名称:

ML-365

中文同义词:

KCNK3小分子抑制剂(ML365);化合物ML365

英文名称:

ML365

英文同义词:

ML365;2-methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide;ML-365; ML365; ML 365;2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide;CS-2437;Benzamide, 2-methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]-

CAS号:

947914-18-3

分子式:

C22H20N2O3

分子量:

360.41

EINECS号:

相关类别:

细胞生物学试剂;API

Mol文件:

947914-18-3.mol

沸点 

429.9±40.0 °C(Predicted)

密度 

1.253±0.06 g/cm3(Predicted)

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

13.21±0.70(Predicted)

生物活性

ML365是一种新型的TASK1或KCNK3小分子抑制剂。

靶点

Target Value TASK1/KCNK3 ()

Target

Value

TASK1/KCNK3 ()

体外研究

ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC 50 = 4 nM) and an automated electrophysiology assay (IC 50 = 16 nM). ML365 displays little or no inhibition at 30 μM of more distantly related potassium channels, Kir2.1, potassium voltage-gated channel, KQT-like subfamily, member 2 (KCNQ2), and human ether-a go-go-related gene (hERG). ML365 does not exhibit acute toxicity in cell-based assays at concentrations up to 30 μM.