槐角苷
中文名称:
槐角苷
中文同义词:
槐角苷;槐属甙;染料木素-4-葡萄糖甙;槐角甙;槐苷;槐属苷(标准品);SOPHORICOSIDE 槐角苷;槐角苷(分析标准品)
英文名称:
Sophoricoside
英文同义词:
5,7-dihydroxy-3-[4-[[3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]phenyl]-1-benzopyran-4-one;SOPHORICOSIDE;ISOGENISTIN;GENISTEIN-4-GLUCOSIDE;GENISTEIN-4-O-GLUCOSIDE;4H-1-Benzopyran-4-one,3-[4-(β-;D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-;Sophoricoside ,98%
CAS号:
152-95-4
分子式:
C21H20O10
分子量:
432.38
EINECS号:
相关类别:
中药对照品;标准品;对照品,标准品;分析标准品;植物提取物;对照品;植提标准品;Miscellaneous Natural Products;Natural Plant Extract;中药标准品;分析试剂标准品;原料;对照品-中药对照品;黄酮;标准品 -中药标准品;分析试剂-标准品;标准品，对照品
Mol文件:
152-95-4.mol
熔点
298°
比旋光度
D20 -47° (pyridine); D20 -32° (10% aq pyridine)
沸点
466.08°C (rough estimate)
密度
1.3597 (rough estimate)
折射率
1.5376 (estimate)
储存条件
Keep in dark place,Inert atmosphere,2-8°C
酸度系数(pKa)
6.45±0.20(Predicted)
最大波长(λmax)
271nm(MeOH)(lit.)
CAS 数据库
152-95-4(CAS DataBase Reference)
概述
现代药理研究表明，槐角苷对慢性肝炎病人的降谷丙转氨酶效果良好，还能同时抑制由巴豆油诱导的耳水肿和角叉菜胶引起的爪水肿。临床研究也证实，槐角苷可用于防治妇女绝经后骨质疏松的症状。
生物活性
Sophoricoside 是一种从槐花中分离得到的异黄酮糖苷，具有抗炎，抗癌和免疫抑制作用。
体外研究
Sophoricoside is an isoflavone glycoside isolated from Sophora japonica and has anti-inflammatory, anti-cancer and immunosuppressive effects. The results show that Sophoricoside (50 μM) significantly inhibits the PMACI-induced histamine release. The inhibition rate reaches up to 30.24%. The maximal rates of TNF-α, IL-8 and IL-6 inhibition by Sophoricoside (50 μM) are approximately 31.42%, 43.43% and 34.24%, respectively. The rates of the levels of Rel/p65 inhibition in nuclear by Sophoricoside (50 μM) is approximately 50.14%. Results show that the enhanced caspase-1 activity induced by PMACI is significantly reduced by Sophoricoside in a dose-dependent manner.
体内研究
When the Sophoricoside is orally administered 1 h before compound 48/80 injections, the scratching behaviors is reduced. The inhibition rate of Sophoricoside (2 mg/kg) is approximately 41.21%. Orally administered Sophoricoside inhibits the scratching behaviors by 47.31%. When mice are treated for 2 weeks with Sophoricoside, the atopic dermatitis is recovered to a significant extent.
化学性质
白色结晶粉末，溶于甲醇，来源于槐角。
用途
升血糖作用；槐角浸羔注射于家兔，能使血糖一时性增高。据南京药物研究所报道，从槐角中提出的染料木素和山柰酚，具有干扰孕卵运输、终止孕卵着床和抗早期妊娠等作用，可能与其雌性激素活性有关；小量长期服用染料木素和槐角甙，对雌性小鼠在不影响交配率和生长的情况下，有显著的抗生育作用。毒性作用，槐角浸羔能使家兔及豚鼠的红细胞减少，尤以荚果作用为大。槐树种子提取液能使兔、猪、人的红细胞凝集，种子、荚、果肉均含有抗A、抗B、抗H凝集素；中国槐为含有植物血凝素类药物，并具有促进淋巴细胞的转化作用
安全说明
22-24/25
海关编码
29329990
