中文名称:

4-[[[2-(环己基亚氨基)-4-甲基-3(2H)-噻唑基]亚氨基]甲基]-1,2,3-苯三醇

中文同义词:

4-[[[2-(环己基亚氨基)-4-甲基-3(2H)-噻唑基]亚氨基]甲基]-1,2,3-苯三醇;MCL-1抑制剂(MIM1)

英文名称:

1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-

英文同义词:

MIM1;4-[[[2-(Cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-1,2,3-benzenetriol;1,2,3-Benzenetriol, 4-[[[2-(cyclohexyliMino)-4-;MIM 1;MIM-1;CS-1192;Inhibitor of Mcl-1;1,2,3-Benzenetriol, 4-[[[2-(cyclohexylimino)-4-methyl-3(2H)-thiazolyl]imino]methyl]-

CAS号:

509102-00-5

分子式:

C17H21N3O3S

分子量:

347.43

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

509102-00-5.mol

沸点 

559.6±60.0 °C(Predicted)

密度 

1.40±0.1 g/cm3(Predicted)

酸度系数(pKa)

7.73±0.45(Predicted)

生物活性

MIM-1 是一种骨髓细胞因子 1 (Mcl-1) 抑制剂。

靶点

Mcl-1

Mcl-1

体外研究

MIM-1 selectively targets the BH3 binding groove of Mcl-1, with Bak-dependent apoptotic activity. To estimate the sensitivity of HA and T98G cells to the apoptosis inhibitor MIM-1, the colorimetric MTT assay is used to detect cell viability and to determine the IC 50 value. The IC 50 value of the HA cell line is almost 5-fold lower (16.10 µM) compared with the IC 50 of the T98G cell line (80.20 µM) after MIM-1 inhibitor treatment.