吡咯烷二硫代甲酸铵盐
中文名称:
吡咯烷二硫代甲酸铵盐
中文同义词:
吡咯烷二硫代甲酸铵;四次甲基二硫代氨基甲酸铵;四亚甲基二硫代氨基甲酸铵;1-吡咯烷硫代羧酸铵盐/吡咯二硫代甲酸铵;1-吡咯烷羰基二硫酸铵盐;N-吡咯烷二硫代甲酸铵;1-吡咯烷硫代羧酸铵盐、吡咯二硫代甲酸铵、1-吡咯烷二硫代羧酸铵盐;吡咯烷二硫代甲酸铵盐
英文名称:
Ammonium 1-pyrrolidinedithiocarbamate
英文同义词:
1-Pyrrolidinecarbodithioic acid, ammonium salt,95%;Ammonium Pyrrolidine-N-dithiocarba;PDTC Pyrrolidinedithiocarbamate, ammonium derivative;Ammonium pyrrolidinedithiocarbamate,1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC;Ammonium pyrrolidine;1-Pyrrolidinecarbodithioic acid, aMMoniuM salt, 98% 25GR;Ammonium Pyrrolidine-N-dithiocarbamate 1-Pyrrolidinecarbodithioic Acid Ammonium Salt Pyrrolidine-N-dithiocarbamic Acid Ammonium Salt;PYRROLIDINE-1-DITHIOCARBOXYLIC ACID AMMO
CAS号:
5108-96-3
分子式:
C5H9NS2.H3N
分子量:
164.3
EINECS号:
225-834-4
相关类别:
有机化工原料;生化试剂;酶抑制剂;细胞信号和神经生物学;细胞生物学试剂;化学试剂;化工原料;Nitric Oxide;细胞生物学;标准品;有机原料;医药中间体;格氏试剂;中药对照品;生化试剂-其他化学试剂;合成材料中间体-高分子材料
Mol文件:
5108-96-3.mol
熔点
153-155 °C(lit.)
密度
1.117 (estimate)
折射率
1.5300 (estimate)
储存条件
Store at +2°C to +8°C.
溶解度
190g/l
形态
Powder/Solid
颜色
White to off-white
PH值
6-7 (50g/l, H2O, 20℃)
水溶解性
50 g/L (20 ºC)
敏感性
Hygroscopic
BRN
3730472
稳定性
Stable. Incompatible with strong oxidizing agents.
CAS 数据库
5108-96-3(CAS DataBase Reference)
EPA化学物质信息
1-Pyrrolidinecarbodithioic acid, ammonium salt (5108-96-3)
用途
吡咯烷二硫代甲酸铵盐在包括金属螯合作用在内的生物化学应用中很有用。它被用来防止一氧化氮合酶的诱导。抑制白血病HL-60细胞的凋亡也是非常重要的。
生物活性
Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidine dithiocarbamate, APDC, PDTC, Pyrrolidine dithiocarbamic acid ammonium salt)是NF-κB的有效抑制剂，抑制IκB磷酸化、阻止NF-κB易位入核并减少下游细胞因子的表达。
靶点
Target Value
NF-κB
()
Target
Value
NF-κB
()
体外研究
Pretreatment of cells with Pyrrolidinedithiocarbamate ammonium (Ammonium pyrrolidinedithiocarbamate; 3-1000 μM) dose-dependently attenuate IL-8 production.
Furthermore, pyrrolidinedithiocarbamate ammonium (100 μM) suppresses the accumulation of IL-8 mRNA.
Pyrrolidinedithiocarbamate ammonium inhibits the activation of NF-κB, because it suppresses both NF-κB DNA binding and NF-κB-dependent transcriptional activity. NF-κB inhibition with pyrrolidinedithiocarbamate ammonium decrease IL-8 production by intestinal epithelial cells.
体内研究
The DSS+pyrrolidinedithiocarbamate ammonium-treated groupII exhibits suppression of shortening of intestinal length and reduction of DAI score. Activated NF-κB level and IL-1β and TNF-α levels are significantly lower in DSS+pyrrolidinedithiocarbamate ammonium-treated groupII. These findings suggest that suppression of NF-κB activity by pyrrolidinedithiocarbamate ammonium can delay the healing of mucosal tissue defects (erosions or ulcers) arising from inflammation, but that it can strongly suppress the expression of inf-lammatory cytokines (IL-1β and TNF-α), resulting in significant alleviation of colitis. pyrrolidinedithiocarbamate ammonium is useful for the treatment of ulcerative colitis.
危险品标志
Xi,Xn
危险类别码
36/37/38-22
安全说明
26-36-37/39
WGK Germany
3
F
3
TSCA
Yes
海关编码
29339990
