中文名称:

白术内酯 I

中文同义词:

白术内酯Ⅰ/苍术内酯I;ATRACTYLENOLIDE I 白术内酯Ⅰ 标准品;白术内酯 I;白术油;白术内酯I(苍术内酯I);白术内酯Ⅰ(标准品);苍术内酯I;ATRACTYLENOLIDE I 白术内酯Ⅰ

英文名称:

Atractylenolide-1

英文同义词:

Atractylenolide I, >99%;ATRACTYLENOLIDE-1;3,8aβ-Dimethyl-5-methylene-2,4,4aα,5,6,7,8,8a-octahydronaphtho[2,3-b]furan-2-one;Eudesma-4(15),7(11),8-trien-12-olide;8,9-Dehydroasterolide;(4aS,8aS)-4a,5,6,7,8,8a-Hexahydro-3,8a-dimethyl-5-methylenenaphtho[2,3-b]furan-2(4H)-one;Atractylenolide Ⅰ;Naphtho[2,3-b]furan-2(4H)-one,4a,5,6,7,8,8a-hexahydro-3,8a-dimethyl-5-methylene-, (4aS,8aS)-

CAS号:

73069-13-3

分子式:

C15H18O2

分子量:

230.3

EINECS号:

相关类别:

单方精油;香精香料;香精香料;天然植物精油;分析试剂标准品;中药对照品;标准品;对照品,标准品;植物提取物;对照品;植提标准品;标准物质;可定制;标准品-中药标准品;标准品 -中药标准品;倍半萜;标准品，对照品

Mol文件:

73069-13-3.mol

熔点 

121-123 °C(Solv: ligroine (8032-32-4))

沸点 

405.0±44.0 °C(Predicted)

密度 

1.12

闪点 

170℃

储存条件 

2-8°C

溶解度 

methanol: soluble1mg/mL, clear, colorless

InChIKey

ZTVSGQPHMUYCRS-SWLSCSKDSA-N

性状

白术油为红棕色油状液体，具有白术独特的香气。其含挥发油1.4%，主要成分为苍术醇（Atractylol）、苍术酮（Atractylon）等，并含有维生素A。 根茎含挥发油约1.4％，油中含苍术酮（a-tractylone）,尚含白术内酯甲、乙（butenolide A,B）、芹烷二烯酮[selina-4(14),7(11)-dien-8-one]、β-芹油烯（β- Se-linene）、桉树萜（aromaden-drene）；另含氧香豆素类（oxicoumarines）、糖类及树脂等。

用途

白术油可用作其他原料药。

生物活性

Atractylenolide I 是从白术根中得到的倍半萜烯，具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。Atractylenolide I 为 TLR4 的拮抗剂，同时在 A375 细胞中，能够降低 JAK2 和 STAT3 的磷酸化水平。

靶点

JAK2, STAT3, TLR4

体外研究

Atractylenolide I (40, 60, 80, 100, 120, 150 μM) dose- and time-dependently reduces the cell viability in human A375 melanoma cells after treatment for 24, 48 and 72 hours. Atractylenolide I (50 and 100 μM) induces apoptosis of A375 cells in a dose-dependent manner at 48 h of treatment. Atractylenolide I (100 μM) significantly reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, without effect on total JAK2 and STAT3. Furthermore, Atractylenolide I inhibits the mRNA expression of STAT3-targeted genes, including Bcl-xL, MMP-2 and MMP-9. Atractylenolide I (up to 100 μM) shows no toxicity in normal cells. Atractylenolide I (25, 50 μM) decreases the Ox-LDL induced TNF-α, IL-6 and NO production in VSMCs. Atractylenolide I (12.5, 25 or 50 μM) significantly reduces the level of MCP-1 and inhibits Ox-LDL-induced VSMCs proliferation and migration. Atractylenolide I (25, 50 μM) inhibits positive staining of foam cells, and also significantly decreases lipid accumulation. Atractylenolide I (50 μM) suppresses p38MAPK and NF-κB p65 expression in VSMCs stimulated by Ox-LDL. Atractylenolide I (1, 10, 100 μM) downregulates paclitaxel-induced expression of VEGF and survivin via MyD88-dependent TLR4 signaling in EOC cells.

体内研究

Atractylenolide I (5, 10 or 20 mg/kg, p.o.) restores the decreased body weight in mice subjected to chronic unpredictable mild stress (CUMS). Atractylenolide I alleviates CUMS-induced depressive-like behavior, attenuates CUMS-induced imbalances in hippocampal neurotransmitter levels and reduces CUMS-induced increases in hippocampal pro-inflammatory cytokine levels and in the NLRP3 inflammasome in the hippocampi of mice.

化学性质 

类白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于白术AtractylodesmacrocephalaKoidz.。

用途 

白术内酯Ⅰ具有抗炎，抗肿瘤作用，调节胃肠道功能，促进营养物质吸收。

用途 

用于含量测定/鉴定/药理实验等。 药理药效:白术内酯Ⅰ能促进胃肠道消化吸收功能,是白术键脾的有效成分之-.具有抗炎、抗肿瘤作用，该成分还具有调节胃肠道功能和促进营养物质吸收的功能。

WGK Germany 

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