中文名称:

动力精核苷

中文同义词:

6-糠醇氨基嘌呤核苷;N-(2-呋喃基甲基)腺苷;激动素核苷;N6-(2-呋喃甲基)腺苷;6-呋喃甲基氨基嘌呤核苷;6-糠基氨基嘌呤核苷;N6-呋喃甲基腺苷;N6-糠基腺苷

英文名称:

KINETIN RIBOSIDE

英文同义词:

n-furfuryl-adenosin;6-FURFURYLAMINOPURINE RIBOSIDE;Kinetin-9-riboside;KINETIN RIBOSIDE;FURFURYLAMINOPURINE RIBOSIDE, 6-;N-(2-furanylmethyl)-1H-purin-6-amine riboside;KINETIN RIBOSIDE PLANT CELL CULTURE*TEST ED;6-Furfurylaminopurine Riboside, N6-Furfuryladenosine

CAS号:

4338-47-0

分子式:

C15H17N5O5

分子量:

347.33

EINECS号:

224-389-3

相关类别:

核苷;细胞生物学试剂;原料;Nucleotides and Nucleosides;Bases Related Reagents;Nucleotides

Mol文件:

4338-47-0.mol

熔点 

152-154 °C

沸点 

683.7±65.0 °C(Predicted)

密度 

1.78±0.1 g/cm3(Predicted)

储存条件 

2-8°C

酸度系数(pKa)

13.11±0.70(Predicted)

InChIKey

RCPMGBAAUYWYDJ-FRJWGUMJSA-N

CAS 数据库

4338-47-0

概述

动力精核苷可用作医药合成中间体，如制备一种新型的核苷类RNA聚合酶抑制剂在制备治疗肠病毒71(EV71)感染疾病药物。如果吸入动力精核苷，请将患者移到新鲜空气处；如果皮肤接触，应脱去污染的衣着，用肥皂水和清水彻底冲洗皮肤，如有不适感，就医；如果眼晴接触，应分开眼睑，用流动清水或生理盐水冲洗，并立即就医；如果食入，立即漱口，禁止催吐，应立即就医。

生物活性

Kinetin riboside是细胞分裂素类似物，可诱导癌症细胞死亡。抑制HCT-15细胞增殖的IC50值为2.5 μM。

靶点

IC50: 2.5 μM (HCT-15 cells)

体外研究

Kinetin riboside displays antiproliferative and apoptogenic activity against various human cancer cell lines. Kinetin riboside is able to inhibit the proliferation in HCT-15 human colon cancer cells in a dose-dependent manner (IC 50 =2.5 μM). Kinetin riboside induces apoptosis in HeLa and mouse melanoma B16F-10 cells. Kinetin riboside disrupts the mitochondrial membrane potential and induces the release of cytochrome c and activation of caspase-3. Bad are up-regulated while Bcl-2 is down-regulated under kinetin riboside exposure.

体内研究

Kinetin riboside significantly suppresses tumor growth. The most effective anti-melanoma response is elicited at 40 mg/kg.

安全说明 

24/25

WGK Germany 

3

RTECS号

AU7400200

海关编码 

29349990