中文名称:

RAD51 INHIBITOR B02

中文同义词:

RAD51抑制剂(RAD51 INHIBITOR B02);化合物B02

英文名称:

3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone

英文同义词:

RAD51 Inhibitor, B02 - CAS 1290541-46-6 - Calbiochem;CS-2461;3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone;RAD51 Inhibitor B02;B02;BO2;(E)-3-benzyl-2-(2-(pyridin-3-yl)vinyl)quinazolin-4(3H)-one;4(3H)-Quinazolinone, 3-(phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-

CAS号:

1290541-46-6

分子式:

C22H17N3O

分子量:

339.39

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

1290541-46-6.mol

储存条件 

2-8°C

溶解度 

DMSO: ≥5mg/mL

形态

powder

颜色

faint yellow to dark yellow

生物活性

RAD51 Inhibitor B02 (B02)是人RAD51的抑制剂，IC50值为27.4 μM。

靶点

IC50: 27.4 μM (hRAD51)

体外研究

RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC 50 =27.4 μM), but not its E. coli homologue RecA (IC 50 >250 μM). The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231.

体内研究

B02 significantly enhances the therapeutic effect of cisplatin on tumor cells in vivo . B02 is tolerated by mice at doses up to 50 mg/kg without obvious body weight loss. No inhibition of tumor growth is observed on mice solely treated by B02. Mice treated with 4 mg/kg cisplatin, however, shows a 33% inhibition of tumor growth. Finally, mice treated with 50 mg/kg B02 and 4 mg/kg cisplatin shows a 66% inhibition of tumor growth.

危险品标志 

Xn

危险类别码 

22

WGK Germany 

3