中文名称:

PDK1 INHIBITOR

中文同义词:

5-脲基-3-[1-(吡咯-2-基)亚乙基]吲哚啉-2-酮;PDK1抑制剂(BX517);化合物BX517

英文名称:

PDK1 Inhibitor

英文同义词:

BX-517;BX517(PDK1 inhibitor2);5-Ureido-3-[1-(pyrrol-2-yl)ethylidene]indolin-2-one;PDK1 Inhibitor 2;CS-1693;PDK1 Inhibitor II;BX-517;BX 517;Urea, [2,3-dihydro-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]-

CAS号:

850717-64-5

分子式:

C15H14N4O2

分子量:

282.3

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

850717-64-5.mol

生物活性

BX517 是一种有效的，选择性的 PDK1 抑制剂，IC50 值为 6 nM。

靶点

IC50: 6 nM (PDK1)

体外研究

BX-517 blocks activation of Akt in tumor cells, is potent with IC 50 of 0.1-1.0 μM. BX-517 blocks AKT2 activation in cells with submicromolar potency. BX-517 is 100-fold selective or better against a panel of seven additional Ser/Thr and Tyr kinases.