中文名称:

BMH-21

中文同义词:

N-[2-(二甲基氨基)乙基]-12-氧代-12H-苯并[G]吡啶并[2,1-B]喹唑啉-4-甲酰胺;RNA POLYMERASE I转录抑制剂(BMH-21);N-(2-(二甲氨基)乙基)-12-氧代-12H-苯并[G]吡啶并[2,1-B]喹唑啉-4-甲酰胺

英文名称:

BMH21

英文同义词:

BMH21;N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide;BMH-21 N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide;N-[2-(Dimethylamino)ethyl]-12-oxo-2H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide;CS-1749;BMH 21;BMH21;BMH-21, >98%;12H-Benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide, N-[2-(dimethylamino)ethyl]-12-oxo-

CAS号:

896705-16-1

分子式:

C21H20N4O2

分子量:

360.41

EINECS号:

809-833-1

相关类别:

小分子抑制剂，天然产物;小分子抑制剂;细胞生物学试剂;医药;Inhibitors

Mol文件:

896705-16-1.mol

储存条件 

2-8°C

溶解度 

DMSO: soluble1mg/mL, clear (warmed)

形态

powder

颜色

light yellow to dark yellow

生物活性

BMH-21是一种DNA嵌入剂，与核糖体DNA结合，并抑制RNA polymerase I (Pol I)转录。

体外研究

BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability.

体内研究

BMH-21 reduces tumor growth in mouse xenografts.

危险品标志 

Xn

危险类别码 

22