中文名称:

坡模酸

中文同义词:

坡模醇酸;坡模酸;坡模醇酸,坡模酸;兰地酸A

英文名称:

POMOLIC ACID

英文同义词:

POMOLIC ACID;3β,19-Dihydroxy-5α-urs-12-en-28-oic acid;3β,19-Dihydroxyurs-12-en-28-oic acid;3β,19α-Dihydroxyurs-12-ene-28-oic acid;Benthamic acid;Urs-12-en-28-oic acid, 3,19-dihydroxy-, (3β)-;Randialic acid A

CAS号:

13849-91-7

分子式:

C30H48O4

分子量:

472.7

EINECS号:

相关类别:

对照品;中药对照品;对照品;三萜;标准品，对照品;Triterpenoids;Miscellaneous Natural Products

Mol文件:

13849-91-7.mol

熔点 

297-299 °C(Solv: chloroform (67-66-3); methanol (67-56-1))

沸点 

586.2±50.0 °C(Predicted)

密度 

1.14±0.1 g/cm3(Predicted)

酸度系数(pKa)

4.48±0.70(Predicted)

生物活性

Randialic acid A (Pomolic acid) 是一种五环三萜烯，是从 Euscaphis japonica 中分离出来的。Randialic acid A (Pomolic acid) 抑制肿瘤细胞的生长并诱导细胞凋亡。 Randialic acid A (Pomolic acid) 有用于前列腺癌的潜力。

靶点

IC50: apoptosis

体外研究

Randialic acid A (Pomolic acid) induces apoptosis of GBM cells as demonstrated by DNA fragmentation.  Pomolic acid-induced apoptosis is dependent on reactive oxygen species (ROS) production. It also induces uncoupling of mitochondria membrane potential and activation of caspase-3 and -9.