1,3-二咖啡酰奎宁酸
中文名称:
1,3-二咖啡酰奎宁酸
中文同义词:
1,3-二咖啡酰奎宁酸 19870-46-3;1,3-二咖啡酰奎宁酸;1,3-二咖啡酰奎宁酸,对照品,;洋蓟素、朝蓟素
英文名称:
CYNARIN
英文同义词:
1,3-Dicaffeoylquinic acid;(1S,3R,4R,5R)-1,3-Bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-4,5-dihydroxycyclohexanecarboxylic acid;Dicaffeoylquinic Acid, 1,5-;(1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylic acid;1,5-di-O-Caffeoylquinic acid;Cyclohexanecarboxylic acid, 1,3-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxy-, (1S,3R,4R,5R)-;(1S,3R,4R,5R)-1,3-bis[[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy]-4,5-dihydroxycyclohexane-1-carboxylicaci
CAS号:
19870-46-3
分子式:
C25H24O12
分子量:
516.45
EINECS号:
214-655-7
相关类别:
其他生化试剂;标准品;对照品,标准品;标准品-中药标准品;标准品，对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol文件:
19870-46-3.mol
沸点
819.9±65.0 °C(Predicted)
密度
1?+-.0.1 g/cm3(Predicted)
储存条件
Keep in dark place,Sealed in dry,2-8°C
溶解度
soluble5mg/mL, clear, colorless to light yellow
形态
neat
酸度系数(pKa)
2.50±0.50(Predicted)
颜色
white to off-white
生物活性
1,3-Dicaffeoylquinic acid是咖啡酰奎宁酸衍生物，具有抗氧化活性和自由基清除活性。
靶点
Akt
PI3K
Akt
PI3K
体外研究
1,3-Dicaffeoylquinic acid shows increased neuronal cell viability against Aβ(42) toxicity in a concentration-dependent manner in neurons. 1,3-Dicaffeoylquinic acid activates both phosphoinositide 3-kinase (PI3K)/Akt and extracellular regulated protein kinase 1/2 (Erk1/2) with stimulating their upstream tyrosine kinase A (Trk A). 1,3-Dicaffeoylquinic acids anti-apoptotic potential is related to the enhanced inactivating phosphorylation of glycogen synthase kinase 3β (GSK3β) and the modulation of expression of apoptosis-related protein Bcl-2/Bax. 1,3-Dicaffeoylquinic acid (10 μM, 20 μM, 50 μM, and 100 μM) significantly increases cell viablity before OGD/reperfusion, and prevents the depletion of GSH under OGD/reperfusion insult. 1,3-Dicaffeoylquinic acid induces nuclear translocation of Nrf2 in OGD/reperfusion treated astrocytes, and induces increased GCL activity, and the effect is lost in Nrf2 siRNA-transfected cells.
体内研究
1,3-Dicaffeoylquinic acid (32.0 mg/kg, p.o.) and 1-O-ABL are absorbed very quickly in Wistar rats. The maximum plasma concentrations for 1,3-Dicaffeoylquinic acid and 1-O-ABL are 44.5 ± 7.1 and 19.1 ± 6.9 ng/mL, respectively.
化学性质
白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于洋蓟叶，朝鲜蓟，森林千里光全草、金银花。
用途
1,5-O-二咖啡酰奎宁酸具有护肝，降低胆醇的作用。
用途
用于含量测定/鉴定/药理实验等。
药理药效:具有氧化、抗炎、抗病毒、抗纤维化、抑制平滑肌收缩、降血脂等诸多作用。
WGK Germany
3
