千里光宁
中文名称:
千里光宁
中文同义词:
千里光宁;千里光寧鹼;千里光宁碱;千里光碱/ 千里光宁
英文名称:
SENECIONINE
英文同义词:
(15cis)-12-Hydroxysenecionan-11,16-dione;12-Hydroxysenecionan-11,16-dione;16-dione,12-hydroxy-senecionan-1;Aureine;Sencionine;Senecionan-11,16-dione, 12-hydroxy-;SENECIONIN;SENECIONINE
CAS号:
130-01-8
分子式:
C18H25NO5
分子量:
335.39
EINECS号:
相关类别:
对照品;植物提取物;植物活性成分;植物提取;对照品;标准品-对照品;生物碱;Alkaloids;标准品，对照品;标准品
Mol文件:
130-01-8.mol
熔点
236 °C(lit.)
比旋光度
D25 -55.1° (c = 0.034 in chloroform)
沸点
472.03°C (rough estimate)
密度
1.266 g/cm3
折射率
1.5100 (estimate)
储存条件
−20°C
酸度系数(pKa)
12.81±0.40(Predicted)
形态
neat
旋光性 (optical activity)
[α]25/D 55.1°, c = 0.034% in chloroform
BRN
8162955
InChIKey
HKODIGSRFALUTA-JTLQZVBZSA-N
EPA化学物质信息
Senecionine (130-01-8)
生物活性
Senecionine (Senecionan-11,16-dione, 12-hydroxy-) 是一种从 Senecio vulgaris 中分离出来的吡咯里西啶生物碱。 Senecionine对动物和人类有毒。
体外研究
Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the worlds flowering plants. Most PAs represent a considerable health hazard to both livestock and humans through the consumption of plants and PA-contaminated products such as milk, honey, herbal teas, and medicines.
体内研究
Upon intravenous administration and oral administration of Senecionine and Adonifoline, significant differences in pharmacokinetics were observed, with the Senecionine and Adonifoline being absorbed fast with lower bioavailability and being quickly metabolized to PA N-oxides and hydroxylation products of PAs or their N-oxides. Senecionine fails to stimulate epoxide hydrase, it diminishs the activity of glutathione-s-transferase, aminopyrine demethylase and AHH. Twice-weekly injections of a third constituent, senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth.
化学性质
白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于菊三七，千里光Senecio scandens Buch.-Ham. ex D. Don，欧洲千里光 Senecio vulgaris L.全草 菊叶千里光 S.chrysanthemoides DC.根 牙克贝千里光 S.jacobaea L.。
用途
千里光宁具有凝血止血、消炎和抗病毒的作用。
用途
用于含量测定/鉴定/药理实验等。
类别
有毒物品
毒性分级
高毒
急性毒性
腹腔-大鼠 LDL0; 33 毫克/公斤; 静脉-小鼠 LD50: 64 毫克/公斤
可燃性危险特性
可燃; 燃烧产生有毒氮氧化物烟雾
储运特性
通风低温干燥; 与库房食品原料分开存放
灭火剂
干粉,泡沫,沙土,二氧化碳, 雾状水
危险品标志
T
危险类别码
25
安全说明
45
危险品运输编号
UN 2811 6.1/PG 3
WGK Germany
3
RTECS号
VT5710000
F
10-23
HazardClass
6.1(a)
PackingGroup
II
毒性
LD50 i.v. in mice: 64.12 ±2.24 mg/kg (Harris)
