中文名称:

ML281

中文同义词:

N-[2-(3,4-二氢-3-氧代-2-喹喔啉基)-4-(1-甲基乙基)苯基]-2-噻吩甲酰胺;STK33抑制剂(ML281);ML281游离态;化合物ML281

英文名称:

ML281

英文同义词:

ML281;N-[2-(3,4-Dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-2-thiophenecarboxamide;CS-2166;ML 281;ML-281;N-(4-isopropyl-2-(3-oxo-3,4-dihydroquinoxalin-2-yl)phenyl)thiophene-2-carboxamide;2-Thiophenecarboxamide, N-[2-(3,4-dihydro-3-oxo-2-quinoxalinyl)-4-(1-methylethyl)phenyl]-

CAS号:

1404437-62-2

分子式:

C22H19N3O2S

分子量:

389.47

EINECS号:

相关类别:

细胞生物学试剂;抑制剂

Mol文件:

1404437-62-2.mol

储存条件 

Keep in dark place,Sealed in dry,2-8°C

生物活性

ML281 是一种有效的 Serine/threonine kinase 33 (STK33) 的选择性抑制剂，IC50值为0.014 μM。ML281 对KRAS依赖性癌细胞系具有选择性的细胞毒性。

靶点

Target Value STK33 (Cell-free assay) 0.014 μM

Target

Value

STK33 (Cell-free assay)

0.014 μM

体外研究

ML281 (10 μM; 72 hours) suppresses cell viability of NCI-H446 cells. Cell Viability Assay Cell Line: NCI-H446 cells Concentration: 10 μM Incubation Time: 72 hours Result: Suppressed cell viability of NCI-H446 cells.

Cell Line:

NCI-H446 cells

Concentration:

10 μM

Incubation Time:

72 hours

Result:

Suppressed cell viability of NCI-H446 cells.