中文同义词:
N-氧化烟酰胺;烟碱-N-氧化物;N-氧代烟酰胺;烟酰胺-N-氧化物;烟酰胺氮氧化物;烟碱-N-氧化物,98%;烟酰胺-N-氧化物 N-氧代烟酰胺;尼克酰胺N氧化物
英文名称:
Nicotinamide-N-oxide
英文同义词:
1-OXY-NICOTINAMIDE;3-(AMINOCARBONYL)PYRIDINIUM-1-OLATE;AKOS 94294;NICOTINAMIDE 1-OXIDE;NICOTINAMIDE N-OXIDE;TIMTEC-BB SBB004187;3-Pyridinecarboxamide, 1-oxide;3-Pyridinecarboxamide,1-oxide(9CI)
相关类别:
生化试剂;医药中间体;核苷，核苷酸，寡核苷酸;小分子抑制剂;无机化工原料;其他原料;生化试剂-维生素;AMIDE;Biochemicals and Reagents;NAD and Analogs;Nucleosides, Nucleotides, Oligonucleotides;Amines;Bases Related Reagents;Heterocycles;Metabolites Impurities;Nicotine Derivatives;Nucleotides;Amines, Heterocycles, Metabolites Impurities, Nicotine Derivatives, Nucleotides, Bases Related Reagents
熔点
291-293 °C (dec.)(lit.)
沸点
253.51°C (rough estimate)
密度
1.3471 (rough estimate)
储存条件
Inert atmosphere,Room Temperature
酸度系数(pKa)
14.38±0.50(Predicted)
CAS 数据库
1986-81-8(CAS DataBase Reference)
生物活性
Nicotinamide N-oxide是生物体内烟酰胺分解代谢物, 是高效选择性的CXCR2受体拮抗剂。
靶点
CXCR2
Human Endogenous Metabolite
CXCR2
Human Endogenous Metabolite
体外研究
Nicotinamide is one of the forms of vitamin B 3 . It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC 50 =10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC 50 =110 nM) and potent inhibitor of neutrophil chemotaxis (IC 50 =170 nM).
用途
烟酰胺N-氧化物是烟酸类相关化合物，用于烟酸相关粒细胞分化的机制的研究 如人类早幼粒细胞性白血病细胞（HL-60）。烟酰胺N-氧化物减少对HL-60细胞株中c-myc的表达。
