中文名称:

N/A

中文同义词:

N-[[4-[(6-氯-3-吡啶基)甲氧基]-3-甲氧基苯基]甲基]-3,4-二甲氧基苯乙胺盐酸盐;PLK1激酶抑制剂(SBE13 HYDROCHLORIDE);SBE13盐酸盐

英文名称:

SBE 13 hydrochloride

英文同义词:

SBE 13 hydrochloride;N-(4-((6-chloropyridin-3-yl)Methoxy)-3-Methoxybenzyl)-2-(3,4-diMethoxyphenyl)ethanaMine hydrochloride;SBE-13 HCl;N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine;N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine hydrochloride;CS-1632;SBE13 HydrochL;SBE 13 hydrochloride >=98% (HPLC)

CAS号:

1052532-15-6

分子式:

C24H28Cl2N2O4

分子量:

479.4

EINECS号:

相关类别:

小分子抑制剂，天然产物;抑制剂;小分子抑制剂;细胞生物学试剂;Inhibitors

Mol文件:

1052532-15-6.mol

储存条件 

Sealed in dry,Room Temperature

溶解度 

DMSO: ≥17mg/mL

形态

powder

颜色

white to tan

生物活性

SBE 13 HCl是一种有效的选择性PLK1抑制剂，IC50为200 pM，选择性比 Aurora A 激酶, Plk2 和 Plk3高4000多倍。

体外研究

SBE 13 decreases cell proliferation in various cancer cell lines, and causes a G2/M arrest followed by apoptosis. In primary cells, SBE 13 does not impair cell cycle and thus proliferation of primary cells. SBE13 in combination with Enzastaurin displays a synergistic reduction of cell proliferation and enhanced apoptosis induction in HCT116(p53-/-) cells.

靶点

PLK1 200 pM (IC 50 ) PLK3 875 nM (IC 50 )

PLK1 200 pM (IC 50 )

PLK3 875 nM (IC 50 )

危险品标志 

Xn

危险类别码 

22

WGK Germany 

3