中文名称:

DOLASTATIN 10

中文同义词:

尾海兔素10, >99%;微管蛋白聚合抑制剂(DOLASTATIN 10);尾海兔素10

英文名称:

dolastatin 10

英文同义词:

(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide;Dolastain10;Dolastatin 10 (NSC-376128);L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl] amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-;dolastatin 10;B720389K560;From dolabella auricularia (sea hare);L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl] amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]-

CAS号:

110417-88-4

分子式:

C42H68N6O6S

分子量:

785.09

EINECS号:

相关类别:

细胞生物学试剂;多肽;抑制剂;精细化工产品;ADCs

Mol文件:

110417-88-4.mol

沸点 

903.6±65.0 °C(Predicted)

密度 

1.116±0.06 g/cm3(Predicted)

酸度系数(pKa)

13.81±0.46(Predicted)

生物活性

Dolastatin 10 (DLS 10) 是一种有效的从海洋软体动物Dolabela auricularia中分离出来的抗有丝分裂肽，抑制微管蛋白聚合。

靶点

Auristatin

Auristatin

体外研究

Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia . These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI 50 values of 10 −5 -10 −6 μg/mL (10 −2 -10 −3 nM) against a similar minipanel of human cell lines. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.

危险品运输编号 

3172

HazardClass 

6.1(b)

PackingGroup 

III