中文同义词:
2-羟基-D-谷氨酸;(R)-2-羟基戊二酸二钠盐;D-2-HYDROXYPENTANEDIOIC ACID鈥NA+;D-伪-HYDROXYGLUTARICACIDDISODIUMSALT;D-2-羟基戊二酸 二钠盐;(R)-2-羟基戊二酸钠;D-A-羟基戊二酸二钠;(R)-2-羟基戊二酸二钠盐, D-A-羟基戊二酸二钠
英文名称:
D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT
英文同义词:
D-alpha-Hydroxyglutaric acid disodiuM salt >=95% (GC);Disodium (R)-2-hydroxyglutarate;D-α-Hydroxyglutaric Acid (sodium salt);D-ALPHA-HYDROXYGLUTARIC ACID DISODIU;D-2-HYDROXYPENTANEDIOIC ACID DISODIUM SALT;D-ALPHA-HYDROXYGLUTARIC ACID DISODIUM SALT;D-A-HYDROXYGLUTARIC ACID DISODIUM;(r)-2-hydroxypentanedioic acid
相关类别:
合成;细胞生物学试剂;氨基酸;保护氨基酸;非天然氨基酸;Aliphatics;Chiral Reagents;Inhibitors
旋光性 (optical activity)
[α]/D 8.5±1.5°, c = 1 in NaOH
InChIKey
DZHFTEDSQFPDPP-HWYNEVGZSA-L
生物活性
Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium)是一种竞争性α-ketoglutarate-dependent dioxygenases抑制剂，其 Ki值为10.87 ± 1.85 mM。
靶点
Target Value
α-ketoglutarate-dependent dioxygenase
α-ketoglutarate-dependent dioxygenase
体外研究
在U-87MG细胞中，(R)-2-Hydroxyglutarate作为α-KG的弱拮抗剂抑制α-KG依赖性组蛋白脱甲基化酶，并增加H3K9和H3K79的二甲基化作用。此外，(R)-2-Hydroxyglutarate抑制ATP合酶与mTOR信号，因此引起生长阻滞和肿瘤细胞杀伤。
体内研究
D-α-Hydroxyglutaric acid strongly inhibits glucose utilization, CO 2 production and the respiratory chain in rat cerebral cortex and human skeletal muscle, as well as in submitochondrial particles from bovine heart, suggesting an impairment of the aerobic metabolism.
D-α-Hydroxyglutaric acid has also been proposed as an endogenous excitotoxic organic acid because it significantly decreased cell viability in neuronal cultures from chick embryo telencephalons and from neonatal rat hippocampus through stimulation of specific NMDA glutamate receptors.
D-α-Hydroxyglutaric acid (0.01-1 mM) significantly increases chemiluminescence and thiobarbituric acid-reactive substances (TBA-RS) and decreased total antioxidant reactivity (TAR) values in the cortical supernatants in 30-day-old-rats.
