中文名称:

360 A 碘化物

中文同义词:

360 A 碘化物;G-四联体结构抑制剂(360A IODIDE)

英文名称:

360 A iodide

英文同义词:

360 A iodide;360A (iodide);3,3-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium] diiodide

CAS号:

737763-37-0

分子式:

I-

分子量:

126.90447

EINECS号:

相关类别:

细胞生物学试剂

Mol文件:

737763-37-0.mol

生物活性

360A iodide 是一种 G-四联体 (G-quadruplex) 的稳定剂，同时可抑制端粒酶 (telomerase) 的活性，在 TRAP-G4 实验中，IC50 值为 300 nM。

靶点

IC50: 300 nM (Telomerase) G-quadruplex

体外研究

360A iodide inhibits telomerase activity and stabilizes G-quadruplex, with an IC 50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC 50 s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions.