中文名称:

(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇

中文同义词:

(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇;(2R)-2-[[6-[(3-氯-4-羧基苯基)氨基]-9-(1-甲基乙基)-9H-嘌呤-2-基]氨基]-3-甲基-1-丁醇(PURVALANOL B(NG 95) );CDK抑制剂(PURVALANOL B)

英文名称:

(2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL

英文同义词:

(2R)-2-[[6-[(3-CHLORO-4-CARBOXYPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL;PURVALANOL B;NG 95;(2R)-2-((6-((3-Chloro-4-carboxyphenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol;NG 95, (2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol;Purvalanol B, >=96%;(R)-2-Chloro-4-((2-((1-hydroxy-3-methylbutan-2-yl)amino)-9-isopropyl-9H-purin-6-yl)amino)benzo;Purvalanol B(NG 95)

CAS号:

212844-54-7

分子式:

C20H25ClN6O3

分子量:

432.9

EINECS号:

相关类别:

细胞生物学试剂;Signalling

Mol文件:

212844-54-7.mol

熔点 

58.5 °C

沸点 

660.6±65.0 °C(Predicted)

密度 

1.43±0.1 g/cm3(Predicted)

储存条件 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

溶解度 

DMSO: 37 mg/mL, soluble

酸度系数(pKa)

2.81±0.25(Predicted)

形态

solid

InChIKey

ZKDXRFMOHZVXSG-HNNXBMFYSA-N

生物活性

Purvalanol B (NG-95) 是一种有效的、选择性的 cyclin-dependent kinase (CDK) 的抑制剂，其对cdc2-cyclin B、CDK2-cyclin A、CDK2-cyclin E和CDK5-p35的IC50值分别为6 nM、6 nM、9 nM和6 nM。

靶点

Target Value cdc2-cyclin B (Cell-free assay) 6 nM CDK2-Cyclin A (Cell-free assay) 6 nM CDK5-P35 (Cell-free assay) 6 nM CDK2-Cyclin E (Cell-free assay) 9 nM

Target

Value

cdc2-cyclin B (Cell-free assay)

6 nM

CDK2-Cyclin A (Cell-free assay)

6 nM

CDK5-P35 (Cell-free assay)

6 nM

CDK2-Cyclin E (Cell-free assay)

9 nM

WGK Germany 

3