中文同义词:
磺胺二甲异恶唑;硫胺多辛;磺胺邻二甲氧嘧啶/磺胺多辛;磺胺多辛 周效磺胺;周效磺胺(磺胺多辛);磺胺邻二甲氧嘧啶;周效磺胺;乙腈中磺胺邻二甲氧嘧啶标准品
英文同义词:
4-amino-n-(5,6-dimethoxy-4-pyrimidinyl)-benzenesulfonamid;6-(4-aminobenzenesulfonamido)-4,5-dimethoxypyrimidine;fanasil;sulforthomidine;6-(4-aminobenzenesulfonamide)-4,5-dimethoxypyrimidine;4-sulfanilamido-5,6-dimethoxypyrimidine;4-AMINO-N-(5,6-DIMETHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE;Sulfadoxine BP2000/USP25
相关类别:
医药化工类;化合物：原料药;生化试剂;磺胺类;代谢组学;医药原料;抗生素;Pharmaceutical intermediate;API;FANASIL;生命科学标准品;代谢途径;医药中间体;小分子抑制剂;原料;合成抗菌药;医药原料药;医用原料;医药、农药及染料中间体;陕西林奈主打产品;化工中间体;Miscellaneous Natural Products;Intermediates Fine Chemicals;Pharmaceuticals;Antibiotics;BacteriostaticAntibiotics;Chemical Structure;OthersAlphabetic;Principle;S;SN - SZ;Amines;Aromatics;Sulfur Selenium Compounds
沸点
298°C (rough estimate)
密度
1.4006 (rough estimate)
储存条件
Keep in dark place,Inert atmosphere,Room temperature
溶解度
Soluble in ethanol ammonium hydroxide (9:1) at 20mg/ml
酸度系数(pKa)
6.16±0.50(Predicted)
水溶解性
209.8mg/L(temperature not stated)
理化性质
周效磺胺别名周效磺胺，磺胺多辛，磺胺邻二甲氧嘧啶。其是一种白色或类白色结晶粉末。主要用于气管炎、肺炎、菌痢、尿路感染、皮肤软组织感染及预防风湿热等。
生物活性
Sulfadoxine (Sulphadoxine) 是一种超长效磺胺类药物，作用于P. Vivax，IC50为249 μg/ml。
体外研究
Sulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasites environment, while in combination, the two substances have a synergistic effect which outbalances that ability [1, 2].
用途
超长效类磺胺药物，用于治疗脑膜炎、尿路感染等
急性毒性
口服-小鼠LD50: 5200 毫克/公斤; 腹腔-小鼠LD50: 2900 毫克/公斤
可燃性危险特性
可燃;燃烧产生有毒氮氧化物和硫氧化物烟雾
毒性
LD50 in mice (microcrystals, mg/kg): 5200 orally, 2900 s.c., 2900 i.p. (Bhni)
