倍他米松戊酸酯

中文名称:

倍他米松戊酸酯

中文同义词:

戊酸倍他米松;倍他米松戊酸酯;倍他米松戊酸酯原料药;倍他米松戊酸酯 现货;倍他米松17-戊酸酯,戊酸倍他米松;倍他米松戊酸酯溶液,100PPM;7戊酸倍他米松;倍他米松戊酸盐

英文名称:

Betamethasone 17-valerate

英文同义词:

pregna-1,4-diene-3,20-dione,9-fluoro-11,21-dihydroxy-16-methyl-17-((1-oxopenty;9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-valerate;9ALPHA-FLUORO-16BETA-METHYLPREDNISOLONE 17-VALERATE;9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 17-VALERATE;1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-9ALPHA-FLUORO-16BETA-METHYL-3,20-DIONE 17-VALERATE;1,4-pregnadiene-11b,17a,21-triol-9a-fluoro-16b-methyl-3,20-dione 17-valerate;9α-Fluoro-16β-methylprednisolone 17-valerate, Betnovate, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17-valerate, 1,4-Pregnadiene-11β,17α,21-triol-9α-fluoro-16β-methyl-3,20-dione 17-valerate;BetaMethasone valerate (Betnovate)

CAS号:

2152-44-5

分子式:

C27H37FO6

分子量:

476.58

EINECS号:

218-439-3

相关类别:

食品添加剂;氨基酸;原料;小分子抑制剂;酯;农业原料;激素;医用原料;医药中间体;医药原料;甾体激素 (激素，糖皮激素);细胞生物学;生物活性小分子;激素及调节内分泌功能类药;肾上腺皮质激素类药;原料药;甾体激素类;中间体;化合物;甾体激素原料药;医药 抗炎、抗过敏及止痒;皮肤类甾体激素;化工原料;添加剂1;API;BETA-VAL;医药原料药;湖南玉新;医药、农药及染料中间体;化学试剂;贝尔卡主打;有机中间体

Mol文件:

2152-44-5.mol

熔点 

183-184°

比旋光度 

D +77° (dioxane)

沸点 

598.9±50.0 °C(Predicted)

密度 

1.1174 (estimate)

储存条件 

2-8°C

溶解度 

Practically insoluble in water, freely soluble in acetone and in methylene chloride, soluble in ethanol (96 per cent).

酸度系数(pKa)

12.90±0.70(Predicted)

形态

neat

Merck 

13,1183

BRN 

4240001

InChIKey

SNHRLVCMMWUAJD-SUYDQAKGSA-N

CAS 数据库

2152-44-5(CAS DataBase Reference)

EPA化学物质信息

.beta.-Methasone 17-valerate (2152-44-5)

用途

倍他米松戊酸酯主要是用于皮肤类炎症的外用药，抑制和减轻皮肤的 瘙痒，红肿等症状，如湿疹，牛皮癣和皮炎。倍他米松戊酸酯属于高效皮质激素具有易吸收，副作用小的特点。

生物活性

Betamethasone Valerate 是一种中等强效的糖皮质激素类固醇，具有抗炎和免疫抑制特性。

靶点

Target Value Glucocorticoid Receptor ()

Target

Value

Glucocorticoid Receptor ()

体内研究

Betamethasone valerate (10 mg; 5 minutes; applied to the irritated site with a micro spatula) ointment inhibits about 50% of the ear edema without thymus atrophy. Betamethasone-17-valerate ointment (50 mg) inhibits homologous passive cutaneous anaphylaxis. Animal Model: Female Sprague-Dawley rats weighing 60-70 g (croton oil edema experiment) Dosage: 10 mg Administration: Applied to the irritated site with a micro spatula; 5 minutes Result: Inhibited about 50% of the ear edema without thymus atrophy.

Animal Model:

Female Sprague-Dawley rats weighing 60-70 g (croton oil edema experiment)

Dosage:

10 mg

Administration:

Applied to the irritated site with a micro spatula; 5 minutes

Result:

Inhibited about 50% of the ear edema without thymus atrophy.

用途 

激素药，抗炎。

危险品标志 

Xn

危险类别码 

48

安全说明 

22-24/25

RTECS号

TU3835000

海关编码 

2937229000