血管紧张素

中文名称:

血管紧张素

中文同义词:

血管紧张素;醋酸血管紧张素 II ANGIOTENSINII ACETATE;[VAL5]-血管紧张素 II 乙酸盐 水合物;ANGIOTENSIN受体激动剂(ANGIOTENSIN II 5-VALINE);血管紧张素 Ⅱ 5-缬氨酸, >99%;[VAL5]-血管紧张素 II;血管紧张素 Ⅱ 5-缬氨酸

英文名称:

Angiotensin acetate

英文同义词:

[VAL5]-ANGIOTENSIN II;[VAL5] ANGIOTENSIN II HUMAN;ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE;DRVYVHPF;5-L-Valine angiotensin II);Angiotensin II 5-valine (Valine angiotensin II;Valine angiotensin II;VALINE ANGIOTENSIN II;5-L-VALINE ANGIOTENSIN II

CAS号:

58-49-1

分子式:

C49H69N13O12

分子量:

1032.17

EINECS号:

相关类别:

多肽-客户肽;多肽中间体;医药原料;多肽;医药原料药;细胞生物学试剂;对照品-中药对照品;现货;药物多肽

Mol文件:

58-49-1.mol

储存条件 

-20°C

密度 

1.45±0.1 g/cm3(Predicted)

形态

powder

酸度系数(pKa)

3.56±0.10(Predicted)

InChIKey

JVCJXRGXGITABA-IAQGTVMASA-N

CAS 数据库

58-49-1

理化性质

血管紧张素是一类具有极强的缩血管和刺激肾上腺皮质分泌醛固酮等作用的肽类物质，参与血压及体液的调节。可分为血管紧张素Ⅰ-Ⅶ，而目前在血管紧张素Ⅰ，血管紧张素Ⅱ，血管紧张素Ⅲ中研究较多。

生物活性

Angiotensin II 5-valine 是血管紧张素受体 (angiotensin receptor) 的激动剂。

靶点

Angiotensin receptor.

体内研究

By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone.

WGK Germany 

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