盐酸苄普地尔

中文名称:

盐酸苄普地尔

中文同义词:

盐酸苄普地尔;1-异丁氧基-2-吡咯烷基-3-(N-苄基苯胺基)丙烷盐酸盐;苄普地尔盐酸盐;苄普地尔盐酸盐水合物

英文名称:

Bepridil hydrochloride

英文同义词:

Bepridil hydrochloride hydrate;3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzylpropylaminehydrochloridehydrate;angopril;l)-,monohydrochloride,monohydrate;Bepridil hydrochloride;1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride;1-Pyrrolideneethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-, monohydrochloride, monohydrate;Unii-4W2p15D93m

CAS号:

74764-40-2

分子式:

C24H37ClN2O2

分子量:

421.01578

EINECS号:

相关类别:

GLIADEL;API

Mol文件:

74764-40-2.mol

熔点 

91 ±2°

储存条件 

Desiccate at RT

形态

powder

颜色

white

生物活性

Bepridil hydrochloride是一种抗心绞痛的药物，是钙离子通道（calcium channel）阻滞剂。它能阻止多种其他离子通道，包括钠离子和钾离子通道。

靶点

Ca 2+

Ca 2+

体外研究

Bepridil hydrochloride hydrate blockades of Ca 2+ -dependent action potentials in vascular smooth muscle of dog coronary artery. Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC 50 s of 0.5 μM and 30 μM, respectively in cultured ventricular cells. Bepridil hydrochloride hydrate decreases I Ks under blockade of I Kr with E4031 (5 μM), in a concentration-dependent manner.

体内研究

Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration.

WGK Germany 

2

RTECS号

UY1162000

毒性

LD50 in mice (mg/kg): 1955 orally, 23.5 i.v. (Mauvernay, 1978)