L-甲基多巴

中文名称:

L-甲基多巴

中文同义词:

L-甲基多巴;2-甲基-3-(3,4-二羟基苯基)-L-丙氨酸;3-(3,4-二羟基苯基)-2-甲基-L-丙氨酸;3-羟基-Α-甲基-L-酪氨酸;3-羟基-beta-甲基-L-酪氨酸水合物;L-甲基多巴水合物;L-甲基多巴(CAS号:41372-08-1);甲基多巴杂质

英文名称:

alpha-Methyldopa sesquihydrate

英文同义词:

(-)-3-(3,4-Dihydroxyphenyl)-2-Methyl-L-alanine sesquihydrate 99%;BPBio1_000365;BSPBio_000331;C07194;IDI1_000142;KBio2_001417;KBio2_003985;KBio2_006553

CAS号:

41372-08-1

分子式:

C10H15NO5

分子量:

229.23

EINECS号:

609-918-1

相关类别:

生化试剂-氨基酸类;化学试剂;中药对照品;原料药API;氨基酸;生化试剂;Amino Acids Derivatives;Chiral Reagents;Intermediates Fine Chemicals;Neurochemicals;Pharmaceuticals;氨基酸及其衍生物;Pharmaceutical intermediates;氨基酸类;医药原料;原料药;原料;医用原料;L-Aromatic Amino Acid Decarboxylase

Mol文件:

41372-08-1.mol

熔点 

>300 °C(lit.)

储存条件 

Refrigerator

溶解度 

Slightly soluble in water, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute mineral acids.

形态

neat

旋光性 (optical activity)

[α]25/D 13°, c = 1 in H2O

水溶解性 

0.1-1 g/100 mL at 23 ºC

敏感性 

Air Light Sensitive

Merck 

13,6080

BRN 

2417244

稳定性

Stable, but may be light sensitive. Very hygroscopic. Undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions. Store under a dry atmosphere.

CAS 数据库

41372-08-1(CAS DataBase Reference)

生物活性

Methyldopa hydrate (L-(-)-α-Methyldopa hydrate) 是一种 α-肾上腺素能激动剂 (对 α2-adrenergic receptors 有选择性)。Methyldopa hydrate 是一种前药，在中枢神经系统中被代谢 (α-Methylepinephrine)。

体内研究

Methyldopa hydrate (L-(-)-α-Methyldopa hydrate; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment. Animal Model: 60-day-old male rats Dosage: 200 mg/kg Administration: i.p. Result: Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.

Animal Model:

60-day-old male rats

Dosage:

200 mg/kg

Administration:

i.p.

Result:

Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.

用途 

是一种β-受体阻滞型心血管药物,对中等程序的原发性和肾性高血压有良好疗效。

危险类别码 

20/21-36/37/38-42/43-65

安全说明 

24/25

WGK Germany 

3

RTECS号

YP2860000

F 

10-23

海关编码 

2922504500