氯化乙酰胆碱

中文名称:

氯化乙酰胆碱

中文同义词:

乙酰氯化胆碱, 2-(乙酰氧基)-N,N,N-三甲基乙铵氯化物;氯化乙酰胆碱;乙酰氯化胆碱;氯化乙酰胆碱(99%);2-(乙酰氧基)-N,N,N-三甲基乙铵氯化物;氯化乙酰胆碱(标准品);ACETYLCHOLINE CHLORIDE 氯化乙酰胆碱;氯化乙酰胆碱, FOR CELL CULTURE

英文名称:

Acetylcholine chloride

英文同义词:

(2-Hydroxyethyl)trimethylammoniumchlorideacetate;2-(acetyloxy)-n,n,n-trimethyl-ethanaminiuchloride;ACETYLCHOLINE CHLORIDE;ACETYLCHOLINI CHLORIDUM;ACH;ACECOLINE;acecholin;acetylcholinehydrochloride

CAS号:

60-31-1

分子式:

C7H16ClNO2

分子量:

181.66

EINECS号:

200-468-8

相关类别:

高纯;小分子抑制剂;细胞生物学;试剂和补充物;细胞信号和神经生物学;医药原料药;化学试剂;核糖、核苷酸及其他类;生化试剂;生物化学品;对照品;其他生化试剂;生化试剂-其他化学试剂;原料药;有机化工原料;医用原料;对照品;标准品 -中药标准品;原料药;标准品，对照品;中药对照品;Ammonium Chlorides (Quaternary);Quaternary Ammonium Compounds;A-AM;Bioactive Small Molecules;Building Blocks;C6 to C7;Carbonyl Compounds;Cell Biology;Chemical Synthesis;Esters;Organic Building Blocks;Intermediates Fine Chemicals;Pharmaceuticals;ACECOLINE

Mol文件:

60-31-1.mol

熔点 

146-150 °C (lit.)

密度 

1.1235 (rough estimate)

折射率 

1.5560 (estimate)

储存条件 

room temp

溶解度 

H2O: 0.1 g/mL, clear, colorless

形态

Crystalline Powder

颜色

White

水溶解性 

Soluble IN COLD WATER

敏感性 

Hygroscopic

Merck 

14,87

BRN 

3571875

稳定性

Stable. Substances to be avoided include strong oxidizing agents. Protect from moisture - very hygroscopic.

CAS 数据库

60-31-1(CAS DataBase Reference)

EPA化学物质信息

Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (60-31-1)

生物活性

化合物Acetylcholine Chloride是一种神经递质，作用于包括人类在内的许多生物的周围神经系统（PNS）和中枢神经系统（CNS）。

靶点

Target Value AChR

Target

Value

AChR

体外研究

Acetylcholine chloride (ACh chloride; 10 μM) opens the calcium channel and the fluorescence value and intracellular free calcium will increase significantly when the medium is with high calcium, while these will decrease when the medium is without calcium in sweat gland epithelial cells.

体内研究

Acetylcholine chloride (ACh chloride; SC; 20 mg/kg; single dose) induces pronounced cholinergic stimulation and increase of mouse survival in experimental infection. Animal Model: Male and female out-bred albino mice weighing 18-22 g (sepsis) Dosage: 20 mg/kg Administration: SC; single dose Result: Significantly reduces mortality of mice from sepsis induced by intraperitoneal injection of 2×10 9 E. coli bacterial bodies and the blood levels of proinflammatory cytokines TNF-α, IL-1β, and IL-6.

Animal Model:

Male and female out-bred albino mice weighing 18-22 g (sepsis)

Dosage:

20 mg/kg

Administration:

SC; single dose

Result:

Significantly reduces mortality of mice from sepsis induced by intraperitoneal injection of 2×10 9 E. coli bacterial bodies and the blood levels of proinflammatory cytokines TNF-α, IL-1β, and IL-6.

化学性质 

白色结晶性粉末，极易吸湿，微氨臭，极咸。Mp149-152℃。10%的水溶液pH值约为5，在热水和碱性溶液易分解。本品易溶于水、乙醇和丙二醇，溶于氯仿和醋酸，不溶于乙醚。低毒，LD50(大鼠，经口)2500 mg/kg。

用途 

用作测定乙酰胆碱酯酶的底物；临床作为胆碱能药物。

生产方法 

以氯乙醇和三甲胺水溶液为起始原料反应，再经乙酸酐酰化，最后精制而成。

类别

有毒物品

毒性分级

中毒

急性毒性

口服- 大鼠 LD50: 2500 毫克/ 公斤; 口服-小鼠 LD50: 3000 毫克/公斤

可燃性危险特性

可燃; 加热分解释放有毒氮氧化物和氯化物烟雾

储运特性

库房通风低温干燥

灭火剂

干粉、泡沫、砂土、二氧化碳, 雾状水

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-37/39-36

WGK Germany 

2

RTECS号

FZ9800000

F 

3-8-10-21

TSCA 

Yes

HazardClass 

IRRITANT

海关编码 

29379000

毒性

LD50 in mice, rats (mg/kg): 20, 22 i.v., 170, 250 s.c., 3000, 2500 i.p. (Molitor)