盐酸美利曲辛

中文名称:

盐酸美利曲辛

中文同义词:

盐酸美利蒽;盐酸美利曲辛;3-[10,10-二甲基-9(10H)-蒽亚基]-N,N-二甲基丙胺盐酸盐;3-[10,10-二甲基-9(10H)- 亚蒽基]-N,N-二甲基丙胺盐酸盐;美利曲辛盐酸盐;盐酸美利曲辛 MELITRACEN 成品工作对照品;盐酸MELITRACEN;盐酸美力他欣

英文名称:

Melitracen hydrochloride

英文同义词:

Melitracen Hydrochlorlde;MELITRACEN HYDROCHLORLD;1-Propanamine, 3-(10,10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-, hydrochloride;MELITRACEN HYDROCHLORID;3-[10,10-dimethyl-9(10H)-anthrylidene]-N,N-dimethylpropylamine hydrochloride;Melitracen hydrochloride;3-(10,10-Dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-1-propanamine Hydrochloride;9-(3-Dimethylaminopropylidene)-10,10-dimethyl-9,10-dihydroanthracene Hydrochloride

CAS号:

10563-70-9

分子式:

C21H26ClN

分子量:

327.89084

EINECS号:

234-150-5

相关类别:

盐酸美利曲辛;医药中间体;医药原料;医药 抗抑郁药;中药对照品;标准品;Antidepressant;Amines;Aromatics;Intermediates Fine Chemicals;Pharmaceuticals;Isotope Labeled Compounds;Isotope Labelled Compounds;化工原料药;化工中间体工业原料

Mol文件:

10563-70-9.mol

熔点 

245-248°C

储存条件 

Refrigerator

CAS 数据库

10563-70-9(CAS DataBase Reference)

生物活性

Melitracen hydrochloride (Thymeol)是一种潜在的dopamine D1/2 receptor拮抗剂，具有抗抑郁作用。

靶点

5-HT receptor

体内研究

Single oral administration of either Imipramine or Melitracen produces a marked and long lasting mydriasis in mice. The mydriatic effect of Melitracen is more marked and longer lasting. Melitracen is more effective with respect to behavioral excitement. Single oral administration of Melitracen produces lowering of the catechol amine levels in the brain stem, the cerebral cortex, the spleen, and the adrenals. No significant changes in catecholamine levels of the brain stem, the cerebral cortex, and the spleen were observed in rats receiving daily doses of Melitracen for 13 and 15 weeks. The adrenalin level in the adrenals, however, is slightly decreased.

毒性

LD50 i.v. in mice: 52 mg/kg (Petersen)