土霉素二水合物

中文名称:

土霉素二水合物

中文同义词:

氧四环素/土霉素 二水合物;二水合土霉素;4-二甲氨基-1,4,4a,5,5a,6,11,12a-八氢-3,5,6,10,12,12a-六羟基-6-甲基-1,11-二氧代-并四苯-2-甲酰胺二水合物;土霉素/ 强力霉素;土霉素注射液;二水土霉素;地霉素;二水土霉素 标准品

英文名称:

Oxytetracycline dihydrate

英文同义词:

OXYTETRACYCLINE DIHYDRATE;4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide dihydrate;DOXYCYCLINE USP 23;OXYCYCLINE;DOXYCYCLINE HYCHLATE;DOXYCYCLINE HCL ( VETERINARY);OXYTETRACYCLINE HCL BP;DOXYCYCLINE HYDRATE BP98 USP23

CAS号:

6153-64-6

分子式:

C22H28N2O11

分子量:

496.46

EINECS号:

612-168-8

相关类别:

小分子抑制剂，天然产物;成药;生化试剂;抗生素;原料药;原料中间体-原料药;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Amines;Chiral Reagents;Intermediates Fine Chemicals;Pharmaceuticals;EUTONYL;医药、农药及染料中间体;添加剂;FINISHED MEDICINE;Chemical Structure Class;Genetic Marker SelectionAntibiotics;Interferes with Protein SynthesisSpectrum of Activity;L - ZAntibiotics;Mechanism of Action;Tetracyclines;Inhibitors

Mol文件:

6153-64-6.mol

熔点 

181-182 °C

比旋光度 

-216 º (c=1,0.1 M HCl)

储存条件 

Sealed in dry,Room Temperature

溶解度 

1 M HCl: 0.1 M yellow to yellow-orange, clear

形态

crystalline

颜色

yellow

水溶解性 

slightly soluble

CAS 数据库

6153-64-6(CAS DataBase Reference)

EPA化学物质信息

Oxytetracycline dihydrate (6153-64-6)

生物活性

Oxytetracycline Dihydrate 是一种处方抗生素，干扰细菌产生必需蛋白质的能力。

靶点

HSV-1 Bacterial Human Endogenous Metabolite

HSV-1

Bacterial

体外研究

Oxytetracycline is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. Oxytetracycline is synthesized by a type II polyketide synthase that generates the poly-beta-ketone backbone through successive decarboxylative condensation of malonyl-CoA extender units, followed by modifications by cyclases, oxygenases, transferases, and additional tailoring enzymes.

体内研究

The effects of administration a therapeutic dose of Oxytetracycline (82.8 mg/kg of bw to 1 % bw/day) for 10 days are species specific. Oxytetracycline increases the relative liver weight in Morone chrysops x M. saxatilis , the enzymatic activity of CYP3A4 in Ictalurus punctatus, protein expression of CYP3A4 in Oreochromis niloticus and depleted the hepatic CYP3A4 in the latter. For Oxytetracycline, the limits are 100 μg/kg in muscle and milk, 200 μg/kg in egg, 300 μg/kg in liver and 600 μg/kg in kidney. Oxytetracycline (OTC) is administered to fish as medicated feed at concentrations ranging from 35 to 75 mg a.i kg-1 biomass day-1 for 7-14 days.

用途 

阻止aminoacyl-tRNA结合到30S亚单元上，抑制蛋白质合成（延长期）。 抗菌谱: 革兰氏阴性和阳性菌

危险品标志 

Xn,Xi

危险类别码 

63-36-36/37/38

安全说明 

22-24/25-36/37/39-26-36

WGK Germany 

3

海关编码 

29413000