离子霉素

中文名称:

离子霉素

中文同义词:

离子霉素, 来源于链霉菌;罗红霉素(游离酸)(链霉菌属载体);离子霉素;来自共生链霉菌的IONOMYCIN;离子霉素(乙醇溶液);IONOMYCIN游离态

英文名称:

IONOMYCIN

英文同义词:

(4R,6S,8R,12R,14S,18S,19R,20R,21R)-19,21-Dihydroxy-22-[(2R,5R)-5-[(2R,5S)-5-(1-hydroxyethyl)-5-methyl-oxolan-2-yl]-5-methyl-oxolan-2-yl]-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxo-docosa-10,16-dienoate calcium salt;SQ-23377;Ionomycin,Free Acid,from Streptomyces conglbatus;(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2R,5S,5S)-octahydro-5-[(1R)-1-hydroxyethyl]-2,5-dimethyl[2,2-bifuran]-5-yl]-9-oxo-10,16-docosadienoicacid;SQ 23377, EM 94;Ionomycin, free acid, from Streptomyces conglobatus;(4R,6S,8S,10Z,12R,14R,16E,18S,19S,20R,21S)-11,19,21-Trihydroxy-22-{(2S,2S,5S,5R)-5-[(1S)-1-hydroxyethyl]-2,5-dimethyloctahydro-2,2-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadi enoic acid;ionomycin calcium salt from streptomyces conglobatus

CAS号:

56092-81-0

分子式:

C41H72O9

分子量:

709.01

EINECS号:

相关类别:

抗生素;微生物代谢物;医药原料;antibiotic;Ion Channels;MiscellaneousMore...Close...;A - KResearch Essentials;Antibacterial;Antibiotics A to;Antibiotics by Application;Antibiotics G-MAntibiotics;AntibioticsAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Chemical Structure Class;Core Bioreagents;Interferes with Cell Membrane Permeability (Ionophores)Antibiotics;Mechanism of Action;Spectrum of Activity;Calcium channel

Mol文件:

56092-81-0.mol

沸点 

817.2±65.0 °C(Predicted)

密度 

1.072±0.06 g/cm3(Predicted)

储存条件 

−20°C

溶解度 

Soluble to 10 mM in Ethanol and to 10 mM in DMSO.

形态

Waxy solid

酸度系数(pKa)

4.77±0.10(Predicted)

BRN 

3642126

生物活性

Ionomycin (SQ23377) 是一种有效的，选择性的钙离子载体 (calcium ionophore)，也是一种由 Streptomyces conglobatus 产生的抗生素。Ionomycin (SQ23377) 对二价阳离子具有高度特异性 (Ca>Mg>Sr=Ba)。Ionomycin (SQ23377) 促进细胞凋亡。Ionomycin (SQ23377) 还诱导蛋白激酶C (PKC) 激活。

靶点

Calcium ionophore

体外研究

Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus . Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca 2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment. Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment.

危险品标志 

Xn,Xi

危险类别码 

22-36/37/38

安全说明 

36-36/37/39-27-26-24/25

WGK Germany 

3

RTECS号

NO0650000

F 

8-10

HazardClass 

3

海关编码 

29419090