盐酸氯哌斯丁

中文名称:

盐酸氯哌斯丁

中文同义词:

盐酸氯哌丁;盐酸氯哌斯汀;盐酸氯哌斯丁;盐酸氯哌丁(咳平);盐酸氯哌斯汀 1KG;氯哌斯汀盐酸盐;咳平盐酸盐;CLOPERASTINE HYDROCHLORIDE 氯哌斯汀盐酸盐

英文名称:

Cloperastine hydrochloride

英文同义词:

1-(2-((p-chloro-alpha-phenylbenzyl)oxy)ethyl)-piperidinhydrochloride;1-(2-(p-cloro-alpha-fenilbenzilossi)etil)piperidinacloridrato;2-piperidinoethylp-chlorobenzhydryletherhydrochloride;cloperastinacloridrato;ht11;hustazol;4-CHLOROBENZHYDRYL 2-[1-PIPERIDYL]-ETHYL ETHER HYDROCHLORIDE;CHLOPERASTINE HYDROCHLORIDE

CAS号:

14984-68-0

分子式:

C20H25Cl2NO

分子量:

366.32

EINECS号:

239-067-8

相关类别:

医药与生物化工;原料药;分析标准品;法医和兽医标准品;小分子抑制剂;医药原料药;原料

Mol文件:

14984-68-0.mol

熔点 

147.9°

储存条件 

Inert atmosphere,Room Temperature

形态

neat

Merck 

14,2395

CAS 数据库

14984-68-0(CAS DataBase Reference)

生物活性

Cloperastine hydrochloride 抑制 hERG K+ 电流，IC50 为 27 nM，这种作用具有浓度依赖性。

靶点

27 nM (K + currents)

体外研究

Cloperastine inhibits the hERG K + currents in a concentrationdependent manner with an IC 50 value of 27 nM. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects.

体内研究

In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD 50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively.

危险品标志 

Xn

危险类别码 

22

安全说明 

36

WGK Germany 

3

RTECS号

TM6491500