N,N,N,N-四(2-吡啶甲基)乙二胺

中文名称:

N,N,N,N-四(2-吡啶甲基)乙二胺

中文同义词:

N,N,N,N-4(2-吡啶甲基)乙二胺;N,N,N,N-四(2-吡啶甲基)乙二胺,室温保存即可;1,2-乙烷二胺, N,N,N,N-四(2-吡啶基甲基)-;N,N,N,N-四(2-吡啶甲基)乙二胺;N,N,N,N-四(2-吡啶甲基)乙二胺;N,N,N,N-四-(2-吡啶基甲基)乙二胺;N,N,N,N-四KIS-(2-吡啶基甲基)乙二胺;N,N,N,N-四-(2-吡啶基甲基)乙二

英文名称:

TPEN

英文同义词:

N,N,N,N-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;TETRAKIS-(2-PYRIDYLMETHYL)ETHYLENEDIAMINE;{2-[BIS(PYRIDIN-2-YLMETHYL)AMINO]ETHYL}BIS(PYRIDIN-2-YLMETHYL)AMINE;TPEN - CAS 16858-02-9 - Calbiochem;N,N,N,N-tetrakis(2-pyridinylmethyl)-1,2-Ethanediamine;CS-960;TPEN;1,2-Ethanediamine, N,N,N,N-tetrakis(2-pyridinylmethyl)-

CAS号:

16858-02-9

分子式:

C26H28N6

分子量:

424.54

EINECS号:

相关类别:

杂环化合物;合成材料中间体;聚合试剂;其它;Apoptosis;Aromatics;Chelating Agents Ligands;Heterocycles;Inhibitors;Apoptosis Inducers

Mol文件:

16858-02-9.mol

熔点 

110-112 °C

沸点 

530.56°C (rough estimate)

密度 

1.3893 (rough estimate)

折射率 

1.4570 (estimate)

储存条件 

Sealed in dry,2-8°C

酸度系数(pKa)

5.19±0.12(Predicted)

形态

Tan solid

BRN 

4211982

CAS 数据库

16858-02-9(CAS DataBase Reference)

生物活性

TPEN (TPEDA) 是一种可透过细胞的重金属螯合剂，可通过负调控细胞内 NO 和 Zn2+ 信号转导来诱导NB4细胞凋亡。TPEN（TPEDA）可能是APL (acute promyelocytic leukemia) 的潜在治疗策略之一。

靶点

Target Value NO ()

Target

Value

NO ()

体外研究

Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. TPEN, a cell-permeable chelator for heavy metal cations with a low affinity for Ca 2+ . In cells stimulated with 10 or 30 μM cadmium chloride, the addition of TPEN at 3 hr after exposure significantly decreases the elevated fura-2 fluorescence ratio to the basal levels within 10 min (119.6±2.4% or 109±1.5% decrease in ΔRatio (F340/F380) induced by 10 or 30 μM cadmium chloride, respectively), suggesting that a cadmium chloride-induced increase in the fura-2 fluorescence ratio is dependent on an increase in intracellular heavy metal cations but not intracellular Ca 2+ . TPEN is a metal chelator, which targets colon cancer cells through redox cycling of copper. TPEN reduces cell viability in a dose- and time-dependent manner. TPEN-induced cell death is also dependent on the redox cycling of copper since the copper chelator neocuproine inhibited DNA damage and reduced pChk1, γ-H2AX, and ATM protein expression. Cell death by low TPEN concentrations, involved ATM/ATR signaling in all 3 cell lines, since pre-incubation with specific inhibitors of ATM and DNA-PK led to the recovery of cells from TPEN-induced DNA damage.

危险品标志 

Xi

危险类别码 

36/37/38

安全说明 

26-36

WGK Germany 

3

F 

8-10-23

海关编码 

29333990