8-(2-羟基苯甲酰胺基)辛酸钠

中文名称:

8-(2-羟基苯甲酰胺基)辛酸钠

中文同义词:

8-(2-羟基苯甲酰胺基)辛酸钠;N-[8-(2-羟苯基)氨基]辛酸钠;SNAC,8-(2-羟基苯甲酰胺基)辛酸钠;N-[8-( 2-羟基苯甲酰基) 氨基] 辛酸钠;8-(2-羟基苯甲酰氨基)辛酸钠;8-水杨酰胺基辛酸钠;8-(2-羟基苯甲酰胺基)辛酸钠SNAC(索马鲁肽关键辅料);沙波立沙钠

英文名称:

sodium,8-[(2-hydroxybenzoyl)amino]octanoate

英文同义词:

sodium,8-[(2-hydroxybenzoyl)amino]octanoate;sodium 8-(2-hydroxybenzamido)octanoate;Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, monosodium salt;SNAC;SNAC,sodium 8-[(2-hydroxybenzoyl)amino]octanoate;Salcaprozate sodium;Salcaprozate Sodium (SNAC);SODIUM 8-(2-HYDROXYBENZAMIDO)OCTANOATE (SNAC)

CAS号:

203787-91-1

分子式:

C15H20NNaO4

分子量:

301.31337

EINECS号:

相关类别:

阿司匹林衍生物;苯类;API

Mol文件:

203787-91-1.mol

储存条件 

Inert atmosphere,Room Temperature

简介

8-(2-羟基苯甲酰胺基)辛酸钠，简称SNAC，是一种二碳磷酸盐化合物吸收促进剂，用于治疗胃肠道疾病，尤其适用于二碳磷酸盐化合物吸收不良引起的肠胃道疾病。

生物活性

Salcaprozate sodium (SNAC) 是一种口服吸收促进剂，有潜力作为口服形式的肝素和胰岛素的递送剂。Salcaprozate sodium 可增加非共价大分子络合引起的亲脂性，从而增加小肠上皮细胞的被动跨细胞渗透。

体外研究

SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL. SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution.

体内研究

SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats. SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident. SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d. Animal Model: Sprague-Dawley rats (6-7 weeks) Dosage: 2000 mg/kg/d Administration: Oral gavage for 13 weeks Result: Induced 20% and 50% mortality in males and females at the dose of 2000 mg/kg/d.

Animal Model:

Sprague-Dawley rats (6-7 weeks)

Dosage:

2000 mg/kg/d

Administration:

Oral gavage for 13 weeks

Result:

Induced 20% and 50% mortality in males and females at the dose of 2000 mg/kg/d.