ANDROPANOLIDE

中文名称:

ANDROPANOLIDE

中文同义词:

英文名称:

Andropanolide

英文同义词:

Andropanolide;2(3H)-Furanone, 3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-, (3Z,4S)-

CAS号:

869807-57-8

分子式:

C20H30O5

分子量:

350.45

EINECS号:

相关类别:

标准品;植物提取物;二萜

Mol文件:

869807-57-8.mol

熔点 

210-211 °C(Solv: methanol (67-56-1))

沸点 

557.3±50.0 °C(Predicted)

密度 

1.21±0.1 g/cm3(Predicted)

酸度系数(pKa)

12.36±0.20(Predicted)

生物活性

Andrographolide (Andro) 穿心莲内酯是通过共价修饰 p50 的半胱氨酸 62 来影响 NF-κB 活性的小拮抗剂。Andrographolide (Andro) 穿心莲内酯是一种双环二萜内酯，主要由穿心莲 (Andrographis paniculate) 产生。 Andrographolide (Andro) 穿心莲内酯抑制刺激的内皮细胞中 NF-κB 的活化，降低细胞粘附分子 E-选择素的表达，阻止 E-选择素介导的白细胞粘附，但对 IκBα 降解，p50 和 p65 核转位没有影响。

体外研究

Andrographolide (15 μM; 12 hours) inhibited the luciferase activities induced by TNF-α in a time-dependent manner with an IC 50 of 10 μM. Cell Proliferation Assay Cell Line: 293 cells Concentration: 15 μM Incubation Time: 12 hours Result: Inhibited NF-κB activation induced by TNF-α.

Cell Line:

293 cells

Concentration:

15 μM

Incubation Time:

12 hours

Result:

Inhibited NF-κB activation induced by TNF-α.