RUTAEVINEXIC ACID

中文名称:

RUTAEVINEXIC ACID

中文同义词:

英文名称:

IsoliMonexic acid

英文同义词:

IsoliMonexic acid;Limonexylic acid;Rutaevinexic acid;(17R,23Xi)-1alpha,4;14,15beta-Diepoxy-17,19,23,23-tetrahydroxy-4,4,8-trimethyl-7-oxo-3,4;16,17-diseco-24-nor-5alpha,13alpha,14beta-chol-20(22)-en-3,16,21-trisaeure-3=>19;Isolimonexin;21=>23-trilacton

CAS号:

73904-93-5

分子式:

C26H30O10

分子量:

502.51

EINECS号:

相关类别:

三萜

Mol文件:

Mol File

熔点 

315-316℃

沸点 

788.3±60.0 °C(Predicted)

密度 

1.49±0.1 g/cm3(Predicted)

酸度系数(pKa)

9.79±0.40(Predicted)

生物活性

Isolimonexic acid 是从柠檬种子中分离得到的一种类柠檬酸，具有抗癌和抗芳香化酶 (anti-aromatase) (IC50=25.60 μM) 特性。

靶点

IC50: 25.60 μM (aromatase)

体外研究

Isolimonexic acid (200 μM; 72 hours) exhibits cytotoxicity on MCF-7 cells and shows no cytotoxicity against the MDA-MB-231 cell lines.Isolimonexic acid (50 μg/ml; 48, 96 and 144 hours) exhibits cell growth inhibition of Panc-28 cells in a time-dependent manner.And it percent inhibition comparison to control cells are 21%, 68%, and 90.58% at 48, 72, and 144 h, respectively.