Β-香树脂酮醇

中文名称:

Β-香树脂酮醇

中文同义词:

BETA-香树脂酮醇;Β-香树脂酮醇;11-氧代-Β-香树脂醇;Β-AMYRENONOL

英文名称:

β-Amyrenonol

英文同义词:

3β-Hydroxy-5α-olean-12-en-11-one;β-Amyrenonol;3β-Hydroxyoleana-12-ene-11-one;beta-AMyrenonol;Olean-12-en-11-one, 3-hydroxy-, (3b)-;Olean-12-en-11-one, 3-hydroxy-, (3β)-

CAS号:

38242-02-3

分子式:

C30H48O2

分子量:

440.7

EINECS号:

相关类别:

标准品;植物提取物;中药对照品;标准品 -对照药材;三萜

Mol文件:

Mol File

CAS 数据库

38242-02-3

生物活性

β-Amyrenonol (11-Oxo-β-amyrin) 是一种甘草根中的齐墩果型三萜，是甘草次酸的前体。β-Amyrenonol 具有抗增殖和抗炎活性，并可作为合成许多三萜类化合物的骨架。

体外研究

β-Amyrenonol (11-Oxo-β-amyrin) inhibits cell growth of HL60 cells with an IC 50 value of 26.3 µM. β-Amyrenonol (11-Oxo-β-amyrin) (100 μM) significantly reduces lipopolysaccharide-induced TNFα release in THP-1 cells. CYP88D6 is characterized by in vitro enzymatic activity assays and shown to catalyze the sequential two-step oxidation of β-amyrin at C-11 to produce β-Amyrenonol (11-Oxo-β-amyrin). CYP88D6 coexpressed with β-amyrin synthase in yeast also catalyzed in vivo oxidation of β-amyrin to β-Amyrenonol.