STRICTOSIDINIC ACID

中文名称:

STRICTOSIDINIC ACID

中文同义词:

英文名称:

Strictosidinic acid

英文同义词:

Strictosidinic acid;(2S,3R,4S)-3-Ethenyl-2-(beta-D-glucopyranosyloxy)-3,4-dihydro-4-[[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]methyl]-2H-pyran-5-carboxylic acid;2H-Pyran-5-carboxylic acid, 3-ethenyl-2-(β-D-glucopyranosyloxy)-3,4-dihydro-4-[[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]methyl]-, (2S,3R,4S)-

CAS号:

150148-81-5

分子式:

C26H32N2O9

分子量:

516.54

EINECS号:

相关类别:

中药对照品;生物碱

Mol文件:

150148-81-5.mol

沸点 

792.8±60.0 °C(Predicted)

密度 

1.50±0.1 g/cm3(Predicted)

酸度系数(pKa)

4.67±0.70(Predicted)

生物活性

Strictosidinic acid 是一种具有口服活性的，从 Psychotria myriantha 叶中分离的糖苷吲哚单萜生物碱，抑制 5-HT 生物合成的前体酶并降低 5-HT 含量。Strictosidinic acid 在小鼠中具有外周镇痛和解热活性。

靶点

5-HT Receptor

5-HT Receptor

体内研究

Strictosidinic acid (20 μg/μl; intra-hippocampal injection) causes a significance of 83.5% reduction in 5-HT levels. Strictosidinic acid (10 mg/kg; i.p.) causes a 63.4% reduction in 5-HT levels and a 67.4% reduction in DOPAC values in male Wistar rats, weighing 200-250 g.